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TPSB2 tryptase beta 2 [ Homo sapiens (human) ]

Gene ID: 64499, updated on 23-Nov-2023


Official Symbol
TPSB2provided by HGNC
Official Full Name
tryptase beta 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000197253 MIM:191081; AllianceGenome:HGNC:14120
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPS2; tryptaseB; tryptaseC
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Biased expression in gall bladder (RPKM 111.5), lung (RPKM 107.8) and 13 other tissues See more
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Genomic context

See TPSB2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1228336..1230184, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1243646..1245495, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1278336..1280185, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 H Neighboring gene uncharacterized LOC124903623 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:1274120-1274306 Neighboring gene uncharacterized LOC124903621 Neighboring gene tryptase gamma 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1288568-1289150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1289151-1289731 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1299161-1299692 Neighboring gene tryptase alpha/beta 1 Neighboring gene tryptase delta 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC39869

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
enables serine-type peptidase activity TAS
Traceable Author Statement
more info
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
tryptase beta-2
mast cell tryptase beta II
mast cell tryptase beta III
testicular tissue protein Li 163

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


  1. NG_032951.2 RefSeqGene

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024164.6NP_077078.5  tryptase beta-2 preproprotein

    See identical proteins and their annotated locations for NP_077078.5

    Status: REVIEWED

    Transcript Variant: This variant (1, coding) represents the protein-coding allele encoded by the GRCh38 reference genome.
    Source sequence(s)
    AC120498, AMYH02031223
    D2E6S0, D2E6S2, O95827, P20231, Q15664, Q9UQI6, Q9UQI7
    A0A140VJT7, A0A384MTT9, Q6B051
    ENSP00000482743.1, ENST00000606293.5
    Conserved Domains (2) summary
    Tryp_SPc; Trypsin-like serine protease
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...


  1. NR_178183.1 RNA Sequence

    Status: REVIEWED

    Transcript Variant: This variant (1, non-coding) represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    1228336..1230184 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060940.1 Alternate T2T-CHM13v2.0

    1243646..1245495 complement
    GenBank, FASTA, Sequence Viewer (Graphics)