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ALG1L2 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2 [ Homo sapiens (human) ]

Gene ID: 644974, updated on 17-Sep-2024

Summary

Official Symbol
ALG1L2provided by HGNC
Official Full Name
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2provided by HGNC
Primary source
HGNC:HGNC:37258
See related
Ensembl:ENSG00000251287 AllianceGenome:HGNC:37258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ALG1L2 in Genome Data Viewer
Location:
3q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (130081831..130098390)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (132825683..132842233)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129800674..129817233)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 21 pseudogene Neighboring gene EVA1C pseudogene 6 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:129775360-129776355 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:129776356-129777350 Neighboring gene long intergenic non-protein coding RNA 2014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20519 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129815614-129816445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:129818109-129818938 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20520 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14732 Neighboring gene uncharacterized LOC124909432 Neighboring gene long intergenic non-protein coding RNA 2021 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:129857063-129857830 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:129871903-129872656 Neighboring gene uncharacterized LOC107986131

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
putative glycosyltransferase ALG1L2
Names
asparagine-linked glycosylation 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136152.1NP_001129624.1  putative glycosyltransferase ALG1L2

    See identical proteins and their annotated locations for NP_001129624.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform (1).
    Source sequence(s)
    BC127756, BI833803
    UniProtKB/Swiss-Prot
    C9J202
    UniProtKB/TrEMBL
    A0A8V8TLI2
    Related
    ENSP00000479850.1, ENST00000425059.1
    Conserved Domains (1) summary
    cl10013
    Location:8206
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RNA

  1. NR_178038.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068275

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    130081831..130098390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    132825683..132842233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)