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ALG1L2 ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2 [ Homo sapiens (human) ]

Gene ID: 644974, updated on 25-Jan-2022

Summary

Official Symbol
ALG1L2provided by HGNC
Official Full Name
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like 2provided by HGNC
Primary source
HGNC:HGNC:37258
See related
Ensembl:ENSG00000251287 AllianceGenome:HGNC:37258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ALG1L2 in Genome Data Viewer
Location:
3q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (130081831..130103799)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (129800674..129817233)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 129 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 21 pseudogene Neighboring gene long intergenic non-protein coding RNA 2014 Neighboring gene family with sequence similarity 86, member A pseudogene Neighboring gene long intergenic non-protein coding RNA 2021 Neighboring gene uncharacterized LOC105374103

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mannosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
putative glycosyltransferase ALG1L2
Names
asparagine-linked glycosylation 1-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136152.1NP_001129624.1  putative glycosyltransferase ALG1L2

    See identical proteins and their annotated locations for NP_001129624.1

    Status: VALIDATED

    Source sequence(s)
    BC127756, BI833803
    UniProtKB/Swiss-Prot
    C9J202
    Related
    ENSP00000479850.1, ENST00000425059.1
    Conserved Domains (1) summary
    cl10013
    Location:8206
    Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    130081831..130103799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453711.1XP_024309479.1  putative glycosyltransferase ALG1L2 isoform X1

    Conserved Domains (1) summary
    cl10013
    Location:10111
    Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
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