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CLDN25 claudin 25 [ Homo sapiens (human) ]

Gene ID: 644672, updated on 23-Nov-2021

Summary

Official Symbol
CLDN25provided by HGNC
Official Full Name
claudin 25provided by HGNC
Primary source
HGNC:HGNC:37218
See related
Ensembl:ENSG00000228607
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. [provided by RefSeq, Jun 2010]
Orthologs
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Genomic context

See CLDN25 in Genome Data Viewer
Location:
11q23.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (113779796..113780485)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113650518..113651207)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zw10 kinetochore protein Neighboring gene ribosomal protein S29 pseudogene 19 Neighboring gene cytochrome c oxidase subunit 7A2 like pseudogene Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 pseudogene Neighboring gene activating transcription factor 4 pseudogene 4

Genomic regions, transcripts, and products

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in tight junction IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101389.1NP_001094859.1  putative claudin-25

    See identical proteins and their annotated locations for NP_001094859.1

    Status: INFERRED

    Source sequence(s)
    CH471065
    Consensus CDS
    CCDS44736.1
    UniProtKB/Swiss-Prot
    C9JDP6
    Related
    ENSP00000396304.2, ENST00000453129.2
    Conserved Domains (1) summary
    cl21598
    Location:26183
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    113779796..113780485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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