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Csnk1d casein kinase 1, delta [ Rattus norvegicus (Norway rat) ]

Gene ID: 64462, updated on 5-Jan-2022

Summary

Official Symbol
Csnk1dprovided by RGD
Official Full Name
casein kinase 1, deltaprovided by RGD
Primary source
RGD:71031
See related
Ensembl:ENSRNOG00000036676
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
This gene encodes a member of the casein kinase I (CKI) family of serine/threonine protein kinases. A highly similar human protein regulates an array of cellular processes by influencing the Wnt and hedgehog signaling pathways. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. [provided by RefSeq, Feb 2014]
Expression
Biased expression in Kidney (RPKM 180.6), Lung (RPKM 178.6) and 9 other tissues See more
Orthologs
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Genomic context

See Csnk1d in Genome Data Viewer
Location:
10q32.3
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (106221992..106256620, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (110147786..110182413, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 57 Neighboring gene hypothetical LOC100364110 Neighboring gene solute carrier family 16 member 3 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene Cd7 molecule

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cilium ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of circadian rhythm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
casein kinase I isoform delta; casein kinase I
Names
CKI-delta
tau-protein kinase CSNK1D
NP_620691.2
XP_008766733.1
XP_038942724.1
XP_038942725.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139060.3NP_620691.2  casein kinase I isoform delta

    See identical proteins and their annotated locations for NP_620691.2

    Status: VALIDATED

    Source sequence(s)
    AB063114, BM392381, CB615084, CV112274, DY312461
    UniProtKB/Swiss-Prot
    Q06486
    Related
    ENSRNOP00000092631.1, ENSRNOT00000106442.1
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    106221992..106256620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086796.1XP_038942724.1  casein kinase I isoform X1

    Related
    ENSRNOP00000015178.5, ENSRNOT00000015178.8
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
  2. XM_039086797.1XP_038942725.1  casein kinase I isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1225
    PKc_like; Protein Kinases, catalytic domain
  3. XM_008768511.2XP_008766733.1  casein kinase I isoform X2

    See identical proteins and their annotated locations for XP_008766733.1

    Related
    ENSRNOP00000051819.4, ENSRNOT00000054936.4
    Conserved Domains (1) summary
    cd14125
    Location:8282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon
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