Format

Send to:

Choose Destination

SGK1 serum/glucocorticoid regulated kinase 1 [ Homo sapiens (human) ]

Gene ID: 6446, updated on 6-Sep-2021

Summary

Official Symbol
SGK1provided by HGNC
Official Full Name
serum/glucocorticoid regulated kinase 1provided by HGNC
Primary source
HGNC:HGNC:10810
See related
Ensembl:ENSG00000118515 MIM:602958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGK
Summary
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Expression
Broad expression in small intestine (RPKM 111.9), gall bladder (RPKM 85.9) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SGK1 in Genome Data Viewer
Location:
6q23.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (134169248..134318112, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (134490384..134639250, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1 pseudogene 7 Neighboring gene RNA, 7SL, cytoplasmic 408, pseudogene Neighboring gene uncharacterized LOC107986646 Neighboring gene ribosomal protein S29 pseudogene 32 Neighboring gene RNA, 5S ribosomal pseudogene 218 Neighboring gene keratin 8 pseudogene 42 Neighboring gene uncharacterized LOC105378009 Neighboring gene SGK1-CHCHD2P4 intergenic CAGE-defined mid-level expression enhancer

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
GeneReviews: Not available
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
GeneReviews: Not available
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies serum/glucocorticoid regulated kinase SGK1 is important for HIV-1 replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables chloride channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables potassium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables protein serine/threonine/tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term memory TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transporter activity TAS
Traceable Author Statement
more info
PubMed 
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of catalytic activity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell growth TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of gastric acid secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
involved_in renal sodium ion absorption TAS
Traceable Author Statement
more info
PubMed 
involved_in sodium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Sgk1
Names
Sgk1 variant i3
serine/threonine protein kinase SGK
NP_001137148.1
NP_001137149.1
NP_001137150.1
NP_001278924.1
NP_005618.2
XP_011534373.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143676.3NP_001137148.1  serine/threonine-protein kinase Sgk1 isoform 2

    See identical proteins and their annotated locations for NP_001137148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.
    Source sequence(s)
    AL135839, AL355881, Z84486
    Consensus CDS
    CCDS47476.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000356832.5, ENST00000367858.10
    Conserved Domains (2) summary
    smart00220
    Location:193450
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05575
    Location:197519
    STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
  2. NM_001143677.2NP_001137149.1  serine/threonine-protein kinase Sgk1 isoform 3

    See identical proteins and their annotated locations for NP_001137149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (3) with a longer and an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AK098509, BP384292, DA309338
    Consensus CDS
    CCDS47477.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000434450.1, ENST00000528577.5
    Conserved Domains (1) summary
    cd05575
    Location:130452
    STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
  3. NM_001143678.2NP_001137150.1  serine/threonine-protein kinase Sgk1 isoform 4

    See identical proteins and their annotated locations for NP_001137150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (4) with a longer and an unique N-terminus compared to isoform 1.
    Source sequence(s)
    AK098509, BP384292, DC428953
    Consensus CDS
    CCDS47478.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000396242.3, ENST00000413996.7
    Conserved Domains (1) summary
    cd05602
    Location:104442
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1
  4. NM_001291995.2NP_001278924.1  serine/threonine-protein kinase Sgk1 isoform 5

    See identical proteins and their annotated locations for NP_001278924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF153609, AK295422, DB450096
    Consensus CDS
    CCDS78184.1
    UniProtKB/Swiss-Prot
    O00141
    UniProtKB/TrEMBL
    B7Z325, E9PR89
    Related
    ENSP00000434302.1, ENST00000475719.6
    Conserved Domains (1) summary
    cl21453
    Location:90384
    PKc_like; Protein Kinases, catalytic domain
  5. NM_005627.4NP_005618.2  serine/threonine-protein kinase Sgk1 isoform 1

    See identical proteins and their annotated locations for NP_005618.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1).
    Source sequence(s)
    AK098509, BP384292, DB450096
    Consensus CDS
    CCDS5170.1
    UniProtKB/Swiss-Prot
    O00141
    Related
    ENSP00000237305.7, ENST00000237305.11
    Conserved Domains (1) summary
    cd05602
    Location:90428
    STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    134169248..134318112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536071.1XP_011534373.1  serine/threonine-protein kinase Sgk1 isoform X1

    See identical proteins and their annotated locations for XP_011534373.1

    UniProtKB/Swiss-Prot
    O00141
    Conserved Domains (2) summary
    smart00220
    Location:193450
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05575
    Location:197519
    STKc_SGK; Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase
Support Center