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NKX2-4 NK2 homeobox 4 [ Homo sapiens (human) ]

Gene ID: 644524, updated on 13-Mar-2020

Summary

Official Symbol
NKX2-4provided by HGNC
Official Full Name
NK2 homeobox 4provided by HGNC
Primary source
HGNC:HGNC:7837
See related
Ensembl:ENSG00000125816 MIM:607808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKX2D; NKX2.4
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NKX2-4 in Genome Data Viewer
Location:
20p11.22
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (21395365..21397526, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (21376005..21378047, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 877, pseudogene Neighboring gene 5'-3' exoribonuclease 2 Neighboring gene uncharacterized LOC105372558 Neighboring gene RN7SK pseudogene 140 Neighboring gene hydroxysteroid 17-beta dehydrogenase 12 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
homeobox protein Nkx-2.4
Names
NK2 transcription factor homolog D
NK2 transcription factor related, locus 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033176.2NP_149416.1  homeobox protein Nkx-2.4

    See identical proteins and their annotated locations for NP_149416.1

    Status: VALIDATED

    Source sequence(s)
    AL158013
    Consensus CDS
    CCDS42855.1
    UniProtKB/Swiss-Prot
    Q9H2Z4
    Related
    ENSP00000345147.4, ENST00000351817.5
    Conserved Domains (1) summary
    pfam00046
    Location:192245
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    21395365..21397526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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