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Isl1 ISL LIM homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64444, updated on 23-Jun-2022

Summary

Official Symbol
Isl1provided by RGD
Official Full Name
ISL LIM homeobox 1provided by RGD
Primary source
RGD:61957
See related
Ensembl:ENSRNOG00000012556 AllianceGenome:RGD:61957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Isl-1; isl-1=homeobox
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and estrogen receptor binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; negative regulation of intracellular estrogen receptor signaling pathway; and positive regulation of insulin secretion. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 21.5), Adrenal (RPKM 20.4) and 3 other tissues See more
Orthologs
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Genomic context

See Isl1 in Genome Data Viewer
Location:
2q14
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (48079412..48090704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (48488911..48501217, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108349948 Neighboring gene RNA, U6 small nuclear 572 Neighboring gene U4 spliceosomal RNA Neighboring gene hypothetical protein LOC499530

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in axon regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac cell fate determination ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac cell fate determination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in innervation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron fate specification ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in peripheral nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peripheral nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of heart rate by cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary heart field specification ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory system development ISO
Inferred from Sequence Orthology
more info
 
involved_in sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord motor neuron cell fate specification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in trigeminal nerve development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visceral motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin gene enhancer protein ISL-1
Names
ISL1 transcription factor LIM/homeodomain (islet-1)
ISL1 transcription factor, LIM/homeodomain 1
isl-1 homeobox
islet-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017339.3NP_059035.3  insulin gene enhancer protein ISL-1

    See identical proteins and their annotated locations for NP_059035.3

    Status: PROVISIONAL

    Source sequence(s)
    S69329
    UniProtKB/Swiss-Prot
    P61374
    Related
    ENSRNOP00000017305.4, ENSRNOT00000017305.6
    Conserved Domains (3) summary
    cd09366
    Location:1771
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:79133
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:181237
    HOX; Homeodomain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    48079412..48090704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103065.1XP_038958993.1  insulin gene enhancer protein ISL-1 isoform X1

    Related
    ENSRNOP00000076523.1, ENSRNOT00000117391.1
    Conserved Domains (3) summary
    cd09366
    Location:1771
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:79133
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:181237
    HOX; Homeodomain
  2. XM_039103066.1XP_038958994.1  insulin gene enhancer protein ISL-1 isoform X2

    Conserved Domains (2) summary
    cd09374
    Location:141
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:89145
    HOX; Homeodomain