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Isl1 ISL LIM homeobox 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64444, updated on 4-Dec-2018

Summary

Official Symbol
Isl1provided by RGD
Official Full Name
ISL LIM homeobox 1provided by RGD
Primary source
RGD:61957
See related
Ensembl:ENSRNOG00000012556
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Isl-1; isl-1=homeobox
Summary
transcription factor; may regulate insulin gene expression or islet cell development [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 21.5), Adrenal (RPKM 20.4) and 3 other tissues See more
Orthologs

Genomic context

See Isl1 in Genome Data Viewer
Location:
2q14
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (48488911..48501217, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (66871790..66883936, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene putative 60S ribosomal protein L39-like 5 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene myosin regulatory light chain 12B-like Neighboring gene uncharacterized LOC108349947

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II activating transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enhancer sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nuclear receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
promoter-specific chromatin binding ISO
Inferred from Sequence Orthology
more info
 
promoter-specific chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
axon regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
cardiac cell fate determination IEA
Inferred from Electronic Annotation
more info
 
cardiac cell fate determination ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell myoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
cardiac right ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac right ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucocorticoid stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
endocardial cushion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
endocardial cushion morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
innervation IEA
Inferred from Electronic Annotation
more info
 
innervation ISO
Inferred from Sequence Orthology
more info
 
mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
neural crest cell migration IEA
Inferred from Electronic Annotation
more info
 
neural crest cell migration ISO
Inferred from Sequence Orthology
more info
 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron fate commitment ISO
Inferred from Sequence Orthology
more info
 
neuron fate specification ISO
Inferred from Sequence Orthology
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
outflow tract septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
pancreas development ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system neuron axonogenesis IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
pharyngeal system development IEA
Inferred from Electronic Annotation
more info
 
pharyngeal system development ISO
Inferred from Sequence Orthology
more info
 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
pituitary gland development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of granulocyte colony-stimulating factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone acetylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 alpha production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1 alpha production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
 
secondary heart field specification IEA
Inferred from Electronic Annotation
more info
 
secondary heart field specification ISO
Inferred from Sequence Orthology
more info
 
sensory system development IEA
Inferred from Electronic Annotation
more info
 
sensory system development ISO
Inferred from Sequence Orthology
more info
 
spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron cell fate specification ISO
Inferred from Sequence Orthology
more info
 
spinal cord motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
trigeminal nerve development IEA
Inferred from Electronic Annotation
more info
 
trigeminal nerve development ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular cardiac muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
 
visceral motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
visceral motor neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
insulin gene enhancer protein ISL-1
Names
ISL1 transcription factor LIM/homeodomain (islet-1)
ISL1 transcription factor, LIM/homeodomain 1
isl-1 homeobox
islet-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017339.3NP_059035.3  insulin gene enhancer protein ISL-1

    See identical proteins and their annotated locations for NP_059035.3

    Status: PROVISIONAL

    Source sequence(s)
    S69329
    UniProtKB/Swiss-Prot
    P61374
    Related
    ENSRNOP00000017305.3, ENSRNOT00000017305.5
    Conserved Domains (3) summary
    cd09366
    Location:1771
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09374
    Location:79133
    LIM2_Isl; The second LIM domain of Isl, a member of LHX protein family
    smart00389
    Location:181237
    HOX; Homeodomain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    48488911..48501217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    43808350..43818250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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