Hsf2 heat shock transcription factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hsf2provided by RGD
Official Full Name: heat shock transcription factor 2provided by RGD
Primary source: RGD:68395
See related: Ensembl:ENSRNOG00000000808 AllianceGenome:RGD:68395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human HSF2 (heat shock transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in Muscle (RPKM 138.9), Testes (RPKM 107.6) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 20q12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (37366301..37393922)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (36819864..36847490)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (38935820..38963444)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis.
Title: Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis.
p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure
Title: p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.
DOX induced mitochondrial ROS release to activate ERK1/2-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo.
Title: Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT(1) R upregulation are required for doxorubicin-induced cardiotoxicity.
The Hsf2 is mainly expressed in round spermatids in control testis. Hsf2 expression is significantly increased in both nuclei and cytoplasm of spermatocytes in 7-day cryptorchid testis.
Title: Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes.
Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy in BC-8 cells.
Title: Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma.
both heat shock transcription 2 is linked to the heat shock response in retinal ganglion cells.
Title: Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heat shock factor protein 2

Names: heat shock factor 2; heat shock transcription factor hsf2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001434554.1 → NP_001421483.1 heat shock factor protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0ABK0L2J2, A6K4B9
NM_001434556.1 → NP_001421485.1 heat shock factor protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I5ZYL7, A6K4C0
NM_001434557.1 → NP_001421486.1 heat shock factor protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I5ZYL7, A6K4C0
NM_031694.3 → NP_113882.1 heat shock factor protein 2 isoform 1

See identical proteins and their annotated locations for NP_113882.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A9K3Y8F3, A6K4B9, F1LQD4, Q9R120

Related

ENSRNOP00000001059.4, ENSRNOT00000001059.6

Conserved Domains (2) summary

smart00415
Location:6 → 110

HSF; heat shock factor

pfam06546
Location:230 → 489

Vert_HS_TF; Vertebrate heat shock transcription factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

37366301..37393922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017601769.3 → XP_017457258.1 heat shock factor protein 2 isoform X2

Related

ENSRNOP00000085150.2, ENSRNOT00000101061.2

Conserved Domains (2) summary

smart00415
Location:1 → 53

HSF; heat shock factor

pfam06546
Location:173 → 450

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006256505.5 → XP_006256567.1 heat shock factor protein 2 isoform X1

Related

ENSRNOP00000102980.1, ENSRNOT00000169499.1

Conserved Domains (2) summary

smart00415
Location:6 → 110

HSF; heat shock factor

pfam06546
Location:230 → 507

Vert_HS_TF; Vertebrate heat shock transcription factor
XM_006256506.5 → XP_006256568.1 heat shock factor protein 2 isoform X2

Conserved Domains (2) summary

smart00415
Location:1 → 53

HSF; heat shock factor

pfam06546
Location:173 → 450

Vert_HS_TF; Vertebrate heat shock transcription factor