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NOM1 nucleolar protein with MIF4G domain 1 [ Homo sapiens (human) ]

Gene ID: 64434, updated on 25-Jan-2022

Summary

Official Symbol
NOM1provided by HGNC
Official Full Name
nucleolar protein with MIF4G domain 1provided by HGNC
Primary source
HGNC:HGNC:13244
See related
Ensembl:ENSG00000146909 MIM:611269; AllianceGenome:HGNC:13244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGD1; C7orf3; PPP1R113
Summary
Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 2.9), lymph node (RPKM 2.8) and 25 other tissues See more
Orthologs
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Genomic context

See NOM1 in Genome Data Viewer
Location:
7q36.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (156949712..156973176)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (156742406..156765870)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375604 Neighboring gene uncharacterized LOC105375605 Neighboring gene MNX1 antisense RNA 2 Neighboring gene motor neuron and pancreas homeobox 1 Neighboring gene MNX1 antisense RNA 1 (head to head)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in hair follicle maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosomal small subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleolar MIF4G domain-containing protein 1
Names
SGD1 homolog
protein phosphatase 1, regulatory subunit 113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353366.2NP_001340295.1  nucleolar MIF4G domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC006357, AY576779
    Conserved Domains (2) summary
    pfam02854
    Location:364560
    MIF4G; MIF4G domain
    cl02653
    Location:656762
    MA3; MA3 domain
  2. NM_138400.2NP_612409.1  nucleolar MIF4G domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_612409.1

    Status: VALIDATED

    Source sequence(s)
    AC006357, AY576779
    Consensus CDS
    CCDS34787.1
    UniProtKB/Swiss-Prot
    Q5C9Z4
    Related
    ENSP00000275820.3, ENST00000275820.4
    Conserved Domains (2) summary
    pfam02854
    Location:363559
    MIF4G; MIF4G domain
    cl02653
    Location:655761
    MA3; MA3 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    156949712..156973176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_927512.3 RNA Sequence

  2. XR_002956483.1 RNA Sequence

  3. XR_927510.3 RNA Sequence

  4. XR_927511.3 RNA Sequence

  5. XR_927513.3 RNA Sequence

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