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MRPS25 mitochondrial ribosomal protein S25 [ Homo sapiens (human) ]

Gene ID: 64432, updated on 3-Nov-2019


Official Symbol
MRPS25provided by HGNC
Official Full Name
mitochondrial ribosomal protein S25provided by HGNC
Primary source
See related
Ensembl:ENSG00000131368 MIM:611987
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Ubiquitous expression in brain (RPKM 11.7), thyroid (RPKM 11.6) and 25 other tissues See more

Genomic context

See MRPS25 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (15042251..15065315, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15083758..15106839, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC105376963 Neighboring gene FGD5 antisense RNA 1 Neighboring gene nuclear receptor subfamily 2 group C member 2 Neighboring gene rabenosyn, RAB effector Neighboring gene ribosomal protein S24 pseudogene 10

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ00023, DKFZp313H0817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
mitochondrial translational termination TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
mitochondrion IDA
Inferred from Direct Assay
more info
ribosome IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
28S ribosomal protein S25, mitochondrial
mitochondrial 28S ribosomal protein S25
mitochondrial small ribosomal subunit protein mS25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022497.5NP_071942.1  28S ribosomal protein S25, mitochondrial

    See identical proteins and their annotated locations for NP_071942.1

    Status: REVIEWED

    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
    Source sequence(s)
    AI288348, AK024433, BC003590, DA729310
    Consensus CDS
    ENSP00000253686.2, ENST00000253686.7
    Conserved Domains (1) summary
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain


  1. NR_135246.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
  2. NR_135247.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    15042251..15065315 complement
    GenBank, FASTA, Sequence Viewer (Graphics)


  1. XR_001740234.2 RNA Sequence

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