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MRPS25 mitochondrial ribosomal protein S25 [ Homo sapiens (human) ]

Gene ID: 64432, updated on 7-Sep-2023

Summary

Official Symbol
MRPS25provided by HGNC
Official Full Name
mitochondrial ribosomal protein S25provided by HGNC
Primary source
HGNC:HGNC:14511
See related
Ensembl:ENSG00000131368 MIM:611987; AllianceGenome:HGNC:14511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mS25; RPMS25; COXPD50; MRP-S25
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in brain (RPKM 11.7), thyroid (RPKM 11.6) and 25 other tissues See more
Orthologs
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Genomic context

See MRPS25 in Genome Data Viewer
Location:
3p25.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (15042251..15065315, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (15044674..15067729, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (15083758..15106822, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene uncharacterized LOC105376963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:14962633-14963132 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:14963648-14964847 Neighboring gene Sharpr-MPRA regulatory region 15385 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14988241-14988930 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14989619-14990306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:14990307-14990994 Neighboring gene FGD5 antisense RNA 1 Neighboring gene nuclear receptor subfamily 2 group C member 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15066535-15067034 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:15139860-15140724 Neighboring gene rabenosyn, RAB effector Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:15149813-15150312 Neighboring gene ribosomal protein S24 pseudogene 10

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ00023, DKFZp313H0817

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
small ribosomal subunit protein mS25
Names
28S ribosomal protein S25, mitochondrial
S25mt
mitochondrial 28S ribosomal protein S25
mitochondrial small ribosomal subunit protein mS25
NP_071942.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022497.5NP_071942.1  small ribosomal subunit protein mS25

    See identical proteins and their annotated locations for NP_071942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supported protein.
    Source sequence(s)
    AI288348, AK024433, BC003590, DA729310
    Consensus CDS
    CCDS2622.1
    UniProtKB/Swiss-Prot
    B4DFJ5, B4DQG6, P82663, Q9H7P5
    UniProtKB/TrEMBL
    A0A8Q3SHU8
    Related
    ENSP00000253686.2, ENST00000253686.7
    Conserved Domains (1) summary
    smart00916
    Location:43108
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

RNA

  1. NR_135246.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090954
    Related
    ENST00000447299.3
  2. NR_135247.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC090954
    Related
    ENST00000695385.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    15042251..15065315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    15044674..15067729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)