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SGCB sarcoglycan beta [ Homo sapiens (human) ]

Gene ID: 6443, updated on 9-Jun-2025
Official Symbol
SGCBprovided by HGNC
Official Full Name
sarcoglycan betaprovided by HGNC
Primary source
HGNC:HGNC:10806
See related
Ensembl:ENSG00000163069 MIM:600900; AllianceGenome:HGNC:10806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A3b; SGC; LGMD2E; LGMDR4
Summary
This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in heart (RPKM 22.7), brain (RPKM 22.7) and 23 other tissues See more
Orthologs
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See SGCB in Genome Data Viewer
Location:
4q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (52020706..52038299, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (55506644..55524238, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (52886872..52904465, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 2 Neighboring gene leucine rich repeat containing 66 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15421 Neighboring gene long intergenic non-protein coding RNA 2480 Neighboring gene H3K27ac hESC enhancers GRCh37_chr4:52917119-52917620 and GRCh37_chr4:52917621-52918120 Neighboring gene spermatogenesis associated 18

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates sarcoglycan, beta in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of dystroglycan complex IEA
Inferred from Electronic Annotation
more info
 
part_of dystrophin-associated glycoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of sarcoglycan complex IEA
Inferred from Electronic Annotation
more info
 
part_of sarcoglycan complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
beta-sarcoglycan
Names
43 kDa dystrophin-associated glycoprotein
43DAG
beta-SG
beta-sarcoglycan(43kD dystrophin-associated glycoprotein)
limb girdle muscular dystrophy 2E (non-linked families)
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008891.1 RefSeqGene

    Range
    5001..22625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_204

mRNA and Protein(s)

  1. NM_000232.5NP_000223.1  beta-sarcoglycan isoform 1

    See identical proteins and their annotated locations for NP_000223.1

    Status: REVIEWED

    Source sequence(s)
    AC093858, AK094731, BC020709, CN483961
    Consensus CDS
    CCDS3488.1
    UniProtKB/Swiss-Prot
    B7Z635, O00661, Q16585
    UniProtKB/TrEMBL
    A0A024RDA3, Q5U0N0, Q6IBJ4
    Related
    ENSP00000370839.6, ENST00000381431.10
    Conserved Domains (1) summary
    pfam04790
    Location:59302
    Sarcoglycan_1; Sarcoglycan complex subunit protein
  2. NM_001440519.1NP_001427448.1  beta-sarcoglycan isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC093858
  3. NM_001440520.1NP_001427449.1  beta-sarcoglycan isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC093858

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    52020706..52038299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416074.1XP_047272030.1  beta-sarcoglycan isoform X1

  2. XM_047416076.1XP_047272032.1  beta-sarcoglycan isoform X2

  3. XM_047416075.1XP_047272031.1  beta-sarcoglycan isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    55506644..55524238 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350714.1XP_054206689.1  beta-sarcoglycan isoform X1

  2. XM_054350716.1XP_054206691.1  beta-sarcoglycan isoform X2

  3. XM_054350715.1XP_054206690.1  beta-sarcoglycan isoform X2