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ZDHHC6 zinc finger DHHC-type palmitoyltransferase 6 [ Homo sapiens (human) ]

Gene ID: 64429, updated on 22-Sep-2022

Summary

Official Symbol
ZDHHC6provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 6provided by HGNC
Primary source
HGNC:HGNC:19160
See related
Ensembl:ENSG00000023041 MIM:618715; AllianceGenome:HGNC:19160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC6; DHHC-6; ZNF376
Summary
Enables palmitoyltransferase activity. Involved in positive regulation of mitochondrial fusion and protein palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 19.0), duodenum (RPKM 17.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZDHHC6 in Genome Data Viewer
Location:
10q25.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (112424412..112447572, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (113315089..113338239, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (114184170..114207330, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2531 Neighboring gene tectorin beta Neighboring gene guanylate cyclase 2G, pseudogene Neighboring gene acyl-CoA synthetase long chain family member 5 Neighboring gene Sharpr-MPRA regulatory region 13267 Neighboring gene vesicle transport through interaction with t-SNAREs 1A Neighboring gene uncharacterized LOC124902503 Neighboring gene microRNA 4295

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21952, FLJ30429

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-cysteine S-stearoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stearoylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC6
Names
stearoyltransferase ZDHHC6
transmembrane protein H4
zinc finger DHHC domain-containing protein 6
zinc finger DHHC-type containing 6
zinc finger protein 376
NP_001290063.1
NP_001338011.1
NP_001338012.1
NP_001338013.1
NP_001338014.1
NP_001338015.1
NP_001350473.1
NP_071939.1
XP_006718012.1
XP_011538393.1
XP_011538395.1
XP_011538397.1
XP_016872051.1
XP_016872052.1
XP_016872053.1
XP_016872055.1
XP_016872056.1
XP_016872057.1
XP_016872058.1
XP_047281609.1
XP_047281610.1
XP_047281611.1
XP_047281612.1
XP_047281613.1
XP_047281614.1
XP_047281615.1
XP_047281616.1
XP_047281617.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303134.2NP_001290063.1  palmitoyltransferase ZDHHC6 isoform 2

    See identical proteins and their annotated locations for NP_001290063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AI695150, BC007213, BX647270, DA745043
    Consensus CDS
    CCDS76335.1
    UniProtKB/Swiss-Prot
    Q9H6R6
    Related
    ENSP00000358412.3, ENST00000369404.3
    Conserved Domains (1) summary
    pfam01529
    Location:91237
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001351082.3NP_001338011.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AC022018, AI695150, AK025605, BX647270, DA745043, DC354896
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    Q9H605
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317394
    SH3; Src Homology 3 domain superfamily
  3. NM_001351083.2NP_001338012.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA936028
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    Q9H605
    Related
    ENSP00000507661.1, ENST00000683895.1
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317394
    SH3; Src Homology 3 domain superfamily
  4. NM_001351084.2NP_001338013.1  palmitoyltransferase ZDHHC6 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA621943, DA936028
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    Q9H605
    Related
    ENSP00000507009.1, ENST00000684507.1
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317394
    SH3; Src Homology 3 domain superfamily
  5. NM_001351085.2NP_001338014.1  palmitoyltransferase ZDHHC6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AI695150, AK025605, BP378060, BX647270, DA745043
    Conserved Domains (2) summary
    cl17036
    Location:213292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49137
    DHHC; DHHC palmitoyltransferase
  6. NM_001351086.2NP_001338015.1  palmitoyltransferase ZDHHC6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AI695150, AK025605, BP378060, BX647270, DA745043, DB122344
    Conserved Domains (1) summary
    cl19890
    Location:52133
    zf-DHHC; DHHC palmitoyltransferase
  7. NM_001363544.2NP_001350473.1  palmitoyltransferase ZDHHC6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC022018, AL157786
    Consensus CDS
    CCDS86144.1
    UniProtKB/TrEMBL
    A0A0D9SEX5
    Related
    ENSP00000507679.1, ENST00000682267.1
    Conserved Domains (1) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
  8. NM_001411066.1NP_001397995.1  palmitoyltransferase ZDHHC6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022018
  9. NM_022494.3NP_071939.1  palmitoyltransferase ZDHHC6 isoform 1

    See identical proteins and their annotated locations for NP_071939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 3, 4 and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AI695150, AK025605, BX647270, DA745043
    Consensus CDS
    CCDS7574.1
    UniProtKB/Swiss-Prot
    Q9H605, Q9H6R6
    Related
    ENSP00000358413.3, ENST00000369405.7
    Conserved Domains (2) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
    cl17036
    Location:317394
    SH3; Src Homology 3 domain superfamily

RNA

  1. NR_147045.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC022018, AI695150, AK025605, AW751101, BX647270, DA745043
    Related
    ENST00000684173.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    112424412..112447572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425653.1XP_047281609.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5
  2. XM_047425660.1XP_047281616.1  palmitoyltransferase ZDHHC6 isoform X9

  3. XM_017016566.3XP_016872055.1  palmitoyltransferase ZDHHC6 isoform X3

  4. XM_047425657.1XP_047281613.1  palmitoyltransferase ZDHHC6 isoform X6

  5. XM_011540091.3XP_011538393.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5
    Related
    ENSP00000508215.1, ENST00000683505.1
    Conserved Domains (1) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
  6. XM_017016564.3XP_016872053.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5
    Related
    ENSP00000486105.1, ENST00000626395.2
    Conserved Domains (1) summary
    pfam01529
    Location:95241
    DHHC; DHHC palmitoyltransferase
  7. XM_047425654.1XP_047281610.1  palmitoyltransferase ZDHHC6 isoform X2

    UniProtKB/TrEMBL
    A0A0D9SEX5
    Related
    ENSP00000508135.1, ENST00000682839.1
  8. XM_047425659.1XP_047281615.1  palmitoyltransferase ZDHHC6 isoform X8

  9. XM_047425656.1XP_047281612.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ40
  10. XM_017016563.3XP_016872052.1  palmitoyltransferase ZDHHC6 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6R6
    Conserved Domains (1) summary
    pfam01529
    Location:91237
    zf-DHHC; DHHC palmitoyltransferase
  11. XM_017016568.3XP_016872057.1  palmitoyltransferase ZDHHC6 isoform X8

    Conserved Domains (2) summary
    cl17036
    Location:213292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49137
    DHHC; DHHC palmitoyltransferase
  12. XM_017016567.3XP_016872056.1  palmitoyltransferase ZDHHC6 isoform X5

  13. XM_011540095.4XP_011538397.1  palmitoyltransferase ZDHHC6 isoform X10

  14. XM_006717949.5XP_006718012.1  palmitoyltransferase ZDHHC6 isoform X4

    See identical proteins and their annotated locations for XP_006718012.1

    UniProtKB/TrEMBL
    A0A804HJ40
    Related
    ENSP00000507345.1, ENST00000682195.1
    Conserved Domains (2) summary
    pfam01529
    Location:95188
    zf-DHHC; DHHC palmitoyltransferase
    cl17036
    Location:263342
    SH3; Src Homology 3 domain superfamily
  15. XM_017016562.3XP_016872051.1  palmitoyltransferase ZDHHC6 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6R6
    Conserved Domains (1) summary
    pfam01529
    Location:91237
    zf-DHHC; DHHC palmitoyltransferase
  16. XM_047425661.1XP_047281617.1  palmitoyltransferase ZDHHC6 isoform X10

  17. XM_011540093.3XP_011538395.1  palmitoyltransferase ZDHHC6 isoform X8

    See identical proteins and their annotated locations for XP_011538395.1

    Conserved Domains (2) summary
    cl17036
    Location:213292
    SH3; Src Homology 3 domain superfamily
    cl19890
    Location:49137
    DHHC; DHHC palmitoyltransferase
  18. XM_047425655.1XP_047281611.1  palmitoyltransferase ZDHHC6 isoform X4

    UniProtKB/TrEMBL
    A0A804HJ40
  19. XM_017016569.2XP_016872058.1  palmitoyltransferase ZDHHC6 isoform X11

  20. XM_047425658.1XP_047281614.1  palmitoyltransferase ZDHHC6 isoform X7

RNA

  1. XR_007061983.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    113315089..113338239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)