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POLR1E RNA polymerase I subunit E [ Homo sapiens (human) ]

Gene ID: 64425, updated on 1-Jun-2020

Summary

Official Symbol
POLR1Eprovided by HGNC
Official Full Name
RNA polymerase I subunit Eprovided by HGNC
Primary source
HGNC:HGNC:17631
See related
Ensembl:ENSG00000137054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A49; PAF53; PRAF1
Expression
Ubiquitous expression in ovary (RPKM 15.6), endometrium (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See POLR1E in Genome Data Viewer
Location:
9p13.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (37485935..37503697)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37485945..37503694)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene glyoxylate and hydroxypyruvate reductase Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene F-box protein 10 Neighboring gene translocase of outer mitochondrial membrane 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) I polypeptide E (POLR1E, 53kDa) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13390, FLJ13970, FLJ43482

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase I transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibrillar center IDA
Inferred from Direct Assay
more info
 
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA49
Names
DNA-directed RNA polymerase I subunit E
RNA polymerase I subunit A49
RNA polymerase I-associated factor 53
polymerase (RNA) I associated factor 1
polymerase (RNA) I polypeptide E, 53kDa
polymerase (RNA) I subunit E

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282766.1NP_001269695.1  DNA-directed RNA polymerase I subunit RPA49 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon the coding region which results in the use of downstream start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK303167, AL158156, BC001337
    UniProtKB/Swiss-Prot
    Q9GZS1
    UniProtKB/TrEMBL
    B4E005
    Conserved Domains (1) summary
    pfam06870
    Location:47341
    RNA_pol_I_A49; A49-like RNA polymerase I associated factor
  2. NM_022490.4NP_071935.1  DNA-directed RNA polymerase I subunit RPA49 isoform 1

    See identical proteins and their annotated locations for NP_071935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL158156
    Consensus CDS
    CCDS6611.1
    UniProtKB/Swiss-Prot
    Q9GZS1
    Related
    ENSP00000367029.4, ENST00000377798.9
    Conserved Domains (1) summary
    pfam06870
    Location:36411
    RNA_pol_I_A49; A49-like RNA polymerase I associated factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    37485935..37503697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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