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Polr1e polymerase (RNA) I polypeptide E [ Mus musculus (house mouse) ]

Gene ID: 64424, updated on 8-Dec-2022

Summary

Official Symbol
Polr1eprovided by MGI
Official Full Name
polymerase (RNA) I polypeptide Eprovided by MGI
Primary source
MGI:MGI:1929022
See related
Ensembl:ENSMUSG00000028318 AllianceGenome:MGI:1929022
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
53kDa; Paf53; Praf1; D030019D19Rik
Summary
Enables RNA polymerase I general transcription initiation factor binding activity. Acts upstream of or within RNA polymerase I preinitiation complex assembly. Located in nucleolus. Part of RNA polymerase I complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human POLR1E (RNA polymerase I subunit E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.3), CNS E14 (RPKM 3.1) and 28 other tissues See more
Orthologs
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Genomic context

See Polr1e in Genome Data Viewer
Location:
4; 4 B1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45018609..45034279)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45018609..45034279)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene F-box protein 10 Neighboring gene predicted gene, 30939 Neighboring gene translocase of outer mitochondrial membrane 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to RNA polymerase I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase I general transcription initiation factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA49
Names
DNA-directed RNA polymerase I subunit E
RNA polymerase I associated factor (Paf53)
RNA polymerase I subunit A49
RNA polymerase I-associated factor 53
polymerase (RNA) I associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285800.1NP_001272729.1  DNA-directed RNA polymerase I subunit RPA49 isoform a

    See identical proteins and their annotated locations for NP_001272729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK083948, AK132556, AL824706
    Consensus CDS
    CCDS71378.1
    UniProtKB/Swiss-Prot
    Q8BQG9, Q8K202
    UniProtKB/TrEMBL
    Q3V1B9
    Related
    ENSMUSP00000029999.9, ENSMUST00000029999.15
    Conserved Domains (1) summary
    pfam06870
    Location:51480
    RNA_pol_I_A49; A49-like RNA polymerase I associated factor
  2. NM_022811.3NP_073722.1  DNA-directed RNA polymerase I subunit RPA49 isoform b

    See identical proteins and their annotated locations for NP_073722.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons that result in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AK083948, AK132556, AL824706
    Consensus CDS
    CCDS18131.1
    UniProtKB/Swiss-Prot
    Q8K202
    UniProtKB/TrEMBL
    Q3V1B9
    Related
    ENSMUSP00000121007.2, ENSMUST00000133157.8
    Conserved Domains (1) summary
    pfam06870
    Location:51432
    RNA_pol_I_A49; A49-like RNA polymerase I associated factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45018609..45034279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)