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PIRT phosphoinositide interacting regulator of transient receptor potential channels [ Homo sapiens (human) ]

Gene ID: 644139, updated on 3-Oct-2020

Summary

Official Symbol
PIRTprovided by HGNC
Official Full Name
phosphoinositide interacting regulator of transient receptor potential channelsprovided by HGNC
Primary source
HGNC:HGNC:37239
See related
Ensembl:ENSG00000233670 MIM:612068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in adrenal (RPKM 1.6), brain (RPKM 1.3) and 7 other tissues See more
Orthologs

Genomic context

See PIRT in Genome Data Viewer
Location:
17p12
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (10822470..10838087, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10725792..10741418, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transmembrane protein 220 Neighboring gene mago homolog 2, pseudogene Neighboring gene TMEM220 antisense RNA 1 Neighboring gene transmembrane protein 238 like Neighboring gene RNA, U6 small nuclear 1065, pseudogene Neighboring gene ribosomal protein L15 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
behavioral response to pain IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to heat IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphoinositide-interacting protein
Names
phosphoinositide-interacting regulator of TRPV1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101387.2NP_001094857.1  phosphoinositide-interacting protein

    See identical proteins and their annotated locations for NP_001094857.1

    Status: VALIDATED

    Source sequence(s)
    AC015908, DC332889
    Consensus CDS
    CCDS45614.1
    UniProtKB/Swiss-Prot
    P0C851
    Related
    ENSP00000462046.1, ENST00000580256.3
    Conserved Domains (1) summary
    pfam15099
    Location:7137
    PIRT; Phosphoinositide-interacting protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    10822470..10838087 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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