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KLHL25 kelch like family member 25 [ Homo sapiens (human) ]

Gene ID: 64410, updated on 22-Aug-2020

Summary

Official Symbol
KLHL25provided by HGNC
Official Full Name
kelch like family member 25provided by HGNC
Primary source
HGNC:HGNC:25732
See related
Ensembl:ENSG00000183655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENC2; ENC-2
Expression
Broad expression in brain (RPKM 6.7), testis (RPKM 5.6) and 23 other tissues See more
Orthologs

Genomic context

See KLHL25 in Genome Data Viewer
Location:
15q25.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (85759326..85794925, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (86302557..86338189, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 13 Neighboring gene RNA, U6 small nuclear 1280, pseudogene Neighboring gene long intergenic non-protein coding RNA 2883 Neighboring gene microRNA 1276 Neighboring gene RNA, U6 small nuclear 231, pseudogene Neighboring gene microRNA 548ap

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
GeneReviews: Not available
Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia.
GeneReviews: Not available
Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12587, FLJ45015

Gene Ontology Provided by GOA

Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul3-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
kelch-like protein 25
Names
BTB/POZ KELCH domain protein
ectoderm-neural cortex protein 2
ectodermal-neural cortex 2
kelch-like 25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022480.4NP_071925.2  kelch-like protein 25

    See identical proteins and their annotated locations for NP_071925.2

    Status: VALIDATED

    Source sequence(s)
    AY764034, DA337553, DB063745
    Consensus CDS
    CCDS10339.1
    UniProtKB/Swiss-Prot
    Q9H0H3
    Related
    ENSP00000336800.5, ENST00000337975.6
    Conserved Domains (6) summary
    smart00612
    Location:389441
    Kelch; Kelch domain
    PHA03098
    Location:39566
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330374
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:36140
    BTB; BTB/POZ domain
    pfam01344
    Location:528572
    Kelch_1; Kelch motif
    pfam07707
    Location:149250
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    85759326..85794925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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