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SFTPD surfactant protein D [ Homo sapiens (human) ]

Gene ID: 6441, updated on 26-Jul-2021

Summary

Official Symbol
SFTPDprovided by HGNC
Official Full Name
surfactant protein Dprovided by HGNC
Primary source
HGNC:HGNC:10803
See related
Ensembl:ENSG00000133661 MIM:178635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP-D; PSP-D; SFTP4; COLEC7
Summary
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Restricted expression toward lung (RPKM 293.0) See more
Orthologs
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Genomic context

See SFTPD in Genome Data Viewer
Location:
10q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (79937740..79982236, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81697496..81708861, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein geranylgeranyltransferase type I subunit beta pseudogene 2 Neighboring gene BMS1 pseudogene 21 Neighboring gene mannose binding lectin 1, pseudogene Neighboring gene DPY19L2 pseudogene 5 Neighboring gene zinc and ring finger 2 pseudogene 3 Neighboring gene C1D nuclear receptor corepressor pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SP-D inhibits HIV-1 gp120-CD4 interaction and acts like cell entry inhibitor of HIV-1 PubMed
env Surfactant protein D (SP-D) binds to HIV-1 gp120 and inhibits HIV infectivity; the binding of SP-D to gp120 depends on glycosylation of gp120 and multimerization of SP-D PubMed
env SP-D enhances the binding of HIV-1 gp120 to iMDDCs and induces viral uptake and transfer of HIV from iMDDCs to CD4+ T cells PubMed
env The binding of sDC-SIGN to HIV-1 gp120 is significantly inhibited by SP-D in a dose-dependent manner, indicating an overlap with the binding site for SP-D PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 binds to surfactant protein D in a dose- and calcium-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 binds to surfactant protein D in a dose- and calcium-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in induction of bacterial agglutination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation by host of symbiont molecular function IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of interleukin-2 production TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of adhesion of symbiont to host epithelial cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokine production NAS
Non-traceable Author Statement
more info
PubMed 
involved_in respiratory gaseous exchange by respiratory system IEA
Inferred from Electronic Annotation
more info
 
involved_in surfactant homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle TAS
Traceable Author Statement
more info
 
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
located_in endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome TAS
Traceable Author Statement
more info
PubMed 
is_active_in multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pulmonary surfactant-associated protein D
Names
collectin-7
lung surfactant protein D
pulmonary surfactant apoprotein
surfactant-associated protein, pulmonary 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042218.1 RefSeqGene

    Range
    5001..16366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003019.5NP_003010.4  pulmonary surfactant-associated protein D precursor

    See identical proteins and their annotated locations for NP_003010.4

    Status: REVIEWED

    Source sequence(s)
    BC022318, BI820265, BM985387
    Consensus CDS
    CCDS7362.1
    UniProtKB/Swiss-Prot
    P35247
    Related
    ENSP00000361366.3, ENST00000372292.8
    Conserved Domains (3) summary
    cd03591
    Location:262375
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:130201
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:224269
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    79937740..79982236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540087.1XP_011538389.1  pulmonary surfactant-associated protein D isoform X1

    See identical proteins and their annotated locations for XP_011538389.1

    UniProtKB/Swiss-Prot
    P35247
    Conserved Domains (3) summary
    cd03591
    Location:262375
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:130201
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:224269
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization
  2. XM_011540088.2XP_011538390.1  pulmonary surfactant-associated protein D isoform X2

    See identical proteins and their annotated locations for XP_011538390.1

    Conserved Domains (3) summary
    cd03591
    Location:223336
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:73132
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:185230
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization
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