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SFTPD surfactant protein D [ Homo sapiens (human) ]

Gene ID: 6441, updated on 11-Sep-2019

Summary

Official Symbol
SFTPDprovided by HGNC
Official Full Name
surfactant protein Dprovided by HGNC
Primary source
HGNC:HGNC:10803
See related
Ensembl:ENSG00000133661 MIM:178635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SP-D; PSP-D; SFTP4; COLEC7
Summary
The protein encoded by this gene is part of the innate immune response, protecting the lungs against inhaled microorganisms and chemicals. The encoded protein may also be involved in surfactant metabolism. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward lung (RPKM 293.0) See more
Orthologs

Genomic context

See SFTPD in Genome Data Viewer
Location:
10q22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (79937740..79982236, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81697496..81708861, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene protein geranylgeranyltransferase type I subunit beta pseudogene 2 Neighboring gene BMS1 pseudogene 21 Neighboring gene mannose binding lectin 1, pseudogene Neighboring gene DPY19L2 pseudogene 5 Neighboring gene zinc and ring finger 2 pseudogene 3 Neighboring gene C1D nuclear receptor corepressor pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env SP-D inhibits HIV-1 gp120-CD4 interaction and acts like cell entry inhibitor of HIV-1 PubMed
env Surfactant protein D (SP-D) binds to HIV-1 gp120 and inhibits HIV infectivity; the binding of SP-D to gp120 depends on glycosylation of gp120 and multimerization of SP-D PubMed
env SP-D enhances the binding of HIV-1 gp120 to iMDDCs and induces viral uptake and transfer of HIV from iMDDCs to CD4+ T cells PubMed
env The binding of sDC-SIGN to HIV-1 gp120 is significantly inhibited by SP-D in a dose-dependent manner, indicating an overlap with the binding site for SP-D PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 binds to surfactant protein D in a dose- and calcium-dependent manner PubMed
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 binds to surfactant protein D in a dose- and calcium-dependent manner PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
defense response to bacterium TAS
Traceable Author Statement
more info
PubMed 
developmental process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
induction of bacterial agglutination IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
PubMed 
lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage chemotaxis TAS
Traceable Author Statement
more info
PubMed 
negative regulation by host of symbiont molecular function IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-2 biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phagocytosis TAS
Traceable Author Statement
more info
PubMed 
reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
regulation of adhesion of symbiont to host epithelial cell IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine production NAS
Non-traceable Author Statement
more info
PubMed 
regulation of immune response TAS
Traceable Author Statement
more info
 
respiratory gaseous exchange IEA
Inferred from Electronic Annotation
more info
 
surfactant homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
surfactant homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
clathrin-coated endocytic vesicle TAS
Traceable Author Statement
more info
 
collagen trimer IEA
Inferred from Electronic Annotation
more info
 
endocytic vesicle TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
multivesicular body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pulmonary surfactant-associated protein D
Names
collectin-7
lung surfactant protein D
pulmonary surfactant apoprotein
surfactant-associated protein, pulmonary 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042218.1 RefSeqGene

    Range
    5001..16366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003019.5NP_003010.4  pulmonary surfactant-associated protein D precursor

    See identical proteins and their annotated locations for NP_003010.4

    Status: REVIEWED

    Source sequence(s)
    BC022318, BI820265, BM985387
    Consensus CDS
    CCDS7362.1
    UniProtKB/Swiss-Prot
    P35247
    Related
    ENSP00000361366.3, ENST00000372292.8
    Conserved Domains (3) summary
    cd03591
    Location:262375
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:130201
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:224269
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    79937740..79982236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540087.1XP_011538389.1  pulmonary surfactant-associated protein D isoform X1

    See identical proteins and their annotated locations for XP_011538389.1

    UniProtKB/Swiss-Prot
    P35247
    Conserved Domains (3) summary
    cd03591
    Location:262375
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:130201
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:224269
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization
  2. XM_011540088.2XP_011538390.1  pulmonary surfactant-associated protein D isoform X2

    See identical proteins and their annotated locations for XP_011538390.1

    Conserved Domains (3) summary
    cd03591
    Location:223336
    CLECT_collectin_like; C-type lectin-like domain (CTLD) of the type found in human collectins including lung surfactant proteins A and D, mannose- or mannan binding lectin (MBL), and CL-L1 (collectin liver 1)
    pfam01391
    Location:73132
    Collagen; Collagen triple helix repeat (20 copies)
    pfam09006
    Location:185230
    Surfac_D-trimer; Lung surfactant protein D coiled-coil trimerization
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