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CDH22 cadherin 22 [ Homo sapiens (human) ]

Gene ID: 64405, updated on 4-Jun-2020

Summary

Official Symbol
CDH22provided by HGNC
Official Full Name
cadherin 22provided by HGNC
Primary source
HGNC:HGNC:13251
See related
Ensembl:ENSG00000149654 MIM:609920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf25; dJ998H6.1
Summary
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.4), skin (RPKM 1.8) and 4 other tissues See more
Orthologs

Genomic context

See CDH22 in Genome Data Viewer
Location:
20q13.12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (46173733..46308498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44802372..44937137, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13 pseudogene 2 Neighboring gene CD40 molecule Neighboring gene solute carrier family 35 member C2 Neighboring gene engulfment and cell motility 2 Neighboring gene uncharacterized LOC105372633

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cadherin 22, type 2 (CDH22) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC39564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
brain development IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion via plasma-membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cadherin-22
Names
PB-cadherin
cadherin 22, type 2
cadherin-like 22
ortholog of rat PB-cadherin
pituitary and brain cadherin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021248.3NP_067071.1  cadherin-22 precursor

    See identical proteins and their annotated locations for NP_067071.1

    Status: REVIEWED

    Source sequence(s)
    AK289584, BC039056, BQ102264
    Consensus CDS
    CCDS13395.1
    UniProtKB/Swiss-Prot
    Q9UJ99
    UniProtKB/TrEMBL
    A8K0L9
    Related
    ENSP00000437790.1, ENST00000537909.4
    Conserved Domains (2) summary
    cd11304
    Location:401495
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:657817
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    46173733..46308498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528994.2XP_011527296.1  cadherin-22 isoform X1

    See identical proteins and their annotated locations for XP_011527296.1

    UniProtKB/Swiss-Prot
    Q9UJ99
    Conserved Domains (2) summary
    cd11304
    Location:401495
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam01049
    Location:657817
    Cadherin_C; Cadherin cytoplasmic region
  2. XM_024451966.1XP_024307734.1  cadherin-22 isoform X2

    Conserved Domains (3) summary
    cd11304
    Location:280374
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:345
    CA; Cadherin repeats
    pfam01049
    Location:527698
    Cadherin_C; Cadherin cytoplasmic region
  3. XM_024451967.1XP_024307735.1  cadherin-22 isoform X3

    Conserved Domains (1) summary
    cd11304
    Location:172253
    Cadherin_repeat; Cadherin tandem repeat domain
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