U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNG1F Zn regulated GTPase metalloprotein activator 1F [ Homo sapiens (human) ]

Gene ID: 644019, updated on 29-Oct-2022

Summary

Official Symbol
ZNG1Fprovided by HGNC
Official Full Name
Zn regulated GTPase metalloprotein activator 1Fprovided by HGNC
Primary source
HGNC:HGNC:31978
See related
Ensembl:ENSG00000215126 AllianceGenome:HGNC:31978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CBWD6; CBWD7
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: suggests misassembly
Expression
Ubiquitous expression in kidney (RPKM 11.5), thyroid (RPKM 10.9) and 25 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNG1F in Genome Data Viewer
Location:
9p11.2
Exon count:
23
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (41131309..41205735, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (42105680..42163687)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (69204538..69262546, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3025 Neighboring gene forkhead box D4 like 6 Neighboring gene protein FRG1B-like Neighboring gene microRNA 4477a

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ40320, FLJ60409, DKFZp686L07117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc-regulated GTPase metalloprotein activator 1F; COBW domain-containing protein 6
Names
COBW domain containing 6
COBW domain containing 7
cobalamin synthase W domain-containing protein 6
cobalamin synthetase W domain-containing protein 6
putative COBW domain-containing protein 7
putative cobalamin synthase W domain-containing protein 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085457.2NP_001078926.1  zinc-regulated GTPase metalloprotein activator 1F isoform 1

    See identical proteins and their annotated locations for NP_001078926.1

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Consensus CDS
    CCDS43827.1
    UniProtKB/Swiss-Prot
    Q4V339
    Related
    ENSP00000366608.4, ENST00000377391.8
    Conserved Domains (3) summary
    COG0523
    Location:42376
    YejR; GTPase, G3E family [General function prediction only]
    pfam07683
    Location:274373
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
    cl21455
    Location:43207
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001386876.1NP_001373805.1  zinc-regulated GTPase metalloprotein activator 1F isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Conserved Domains (3) summary
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]
    cd03112
    Location:43226
    CobW-like; cobalamin synthesis protein CobW
    pfam07683
    Location:254353
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  3. NM_001386877.1NP_001373806.1  zinc-regulated GTPase metalloprotein activator 1F isoform 3

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Conserved Domains (2) summary
    COG0523
    Location:42327
    YejR; GTPase, G3E family [General function prediction only]
    COG3044
    Location:1962
    COG3044; Predicted ATPase of the ABC class [General function prediction only]

RNA

  1. NR_170339.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BX255923
    Related
    ENST00000494538.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    41131309..41205735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015028.2XP_016870517.1  COBW domain-containing protein 6 isoform X10

  2. XM_047423722.1XP_047279678.1  COBW domain-containing protein 6 isoform X10

  3. XM_047423720.1XP_047279676.1  COBW domain-containing protein 6 isoform X6

  4. XM_017015025.2XP_016870514.1  COBW domain-containing protein 6 isoform X5

  5. XM_017015022.2XP_016870511.1  COBW domain-containing protein 6 isoform X3

  6. XM_017015023.2XP_016870512.1  COBW domain-containing protein 6 isoform X4

  7. XM_017015021.2XP_016870510.1  COBW domain-containing protein 6 isoform X2

  8. XM_047423721.1XP_047279677.1  COBW domain-containing protein 6 isoform X8

  9. XM_017015026.2XP_016870515.1  COBW domain-containing protein 6 isoform X7

  10. XM_017015019.2XP_016870508.1  COBW domain-containing protein 6 isoform X1

  11. XM_017015036.2XP_016870525.1  COBW domain-containing protein 6 isoform X20

  12. XM_024447653.2XP_024303421.1  COBW domain-containing protein 6 isoform X19

    Conserved Domains (2) summary
    COG0523
    Location:42347
    YejR; GTPase, G3E family [General function prediction only]
    cl26601
    Location:1962
    ABC_ATPase; Predicted ATPase of the ABC class
  13. XM_017015035.2XP_016870524.1  COBW domain-containing protein 6 isoform X18

    UniProtKB/TrEMBL
    H0Y5V3
    Related
    ENSP00000401079.2, ENST00000456520.5
  14. XM_047423723.1XP_047279679.1  COBW domain-containing protein 6 isoform X15

  15. XM_017015029.3XP_016870518.1  COBW domain-containing protein 6 isoform X11

  16. XM_017015034.1XP_016870523.1  COBW domain-containing protein 6 isoform X17

  17. XM_017015033.1XP_016870522.1  COBW domain-containing protein 6 isoform X16

  18. XM_024447652.1XP_024303420.1  COBW domain-containing protein 6 isoform X14

    Conserved Domains (1) summary
    cl26870
    Location:20208
    CobW_C; Cobalamin synthesis protein cobW C-terminal domain
  19. XM_017015031.1XP_016870520.1  COBW domain-containing protein 6 isoform X13

  20. XM_017015030.2XP_016870519.1  COBW domain-containing protein 6 isoform X12

  21. XM_017015027.2XP_016870516.1  COBW domain-containing protein 6 isoform X9

RNA

  1. XR_001746362.2 RNA Sequence

  2. XR_001746359.2 RNA Sequence

  3. XR_007061337.1 RNA Sequence

  4. XR_001746361.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    42105680..42163687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)