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ZNF106 zinc finger protein 106 [ Homo sapiens (human) ]

Gene ID: 64397, updated on 8-Oct-2018

Summary

Official Symbol
ZNF106provided by HGNC
Official Full Name
zinc finger protein 106provided by HGNC
Primary source
HGNC:HGNC:12886
See related
Ensembl:ENSG00000103994 Vega:OTTHUMG00000173244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH3BP3; ZFP106; ZNF474
Expression
Broad expression in heart (RPKM 62.5), fat (RPKM 20.4) and 22 other tissues See more
Orthologs

Genomic context

See ZNF106 in Genome Data Viewer
Location:
15q15.1
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (42412437..42491197, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42705016..42783390, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene BCL2 interacting protein 3 pseudogene 5 Neighboring gene uncharacterized LOC105370794 Neighboring gene calpain 3 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34610, FLJ45841, DKFZp451A239, DKFZp686N20157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 106
Names
SH3-domain binding protein 3
zinc finger protein 474

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284306.1NP_001271235.1  zinc finger protein 106 isoform 2

    See identical proteins and their annotated locations for NP_001271235.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AF205632, AI658947, AK091929, AL831983
    Consensus CDS
    CCDS61602.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    UniProtKB/TrEMBL
    A0A0C4DGM5
    Related
    ENSP00000457637.1, OTTHUMP00000250323, ENST00000565611.5, OTTHUMT00000422589
    Conserved Domains (3) summary
    COG2319
    Location:565993
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:710987
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:760799
    7WD40; WD40 repeat [structural motif]
  2. NM_001284307.1NP_001271236.1  zinc finger protein 106 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and contains multiple alternate 5' coding exons, compared to variant 1. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF205632, AI658947, AK226132, DC403912
    Consensus CDS
    CCDS61603.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    Related
    ENSP00000455674.1, OTTHUMP00000253651, ENST00000565380.5, OTTHUMT00000429959
    Conserved Domains (3) summary
    COG2319
    Location:6081036
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:7531030
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:803842
    7WD40; WD40 repeat [structural motif]
  3. NM_022473.2NP_071918.1  zinc finger protein 106 isoform 1

    See identical proteins and their annotated locations for NP_071918.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF205632, AI658947, AK091929
    Consensus CDS
    CCDS32208.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    Related
    ENSP00000263805.4, OTTHUMP00000250269, ENST00000263805.8, OTTHUMT00000422587
    Conserved Domains (4) summary
    pfam09528
    Location:302839
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG2319
    Location:13801808
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:15251802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:15751614
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    42412437..42491197 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254591.2XP_005254648.1  zinc finger protein 106 isoform X1

    Related
    ENSP00000456845.2, ENST00000564754.6
    Conserved Domains (5) summary
    pfam09528
    Location:325862
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG2319
    Location:14031831
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:15481825
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:15981637
    7WD40; WD40 repeat [structural motif]
  2. XM_017022485.2XP_016877974.1  zinc finger protein 106 isoform X5

    Related
    ENSP00000456604.1, OTTHUMP00000250321, ENST00000565500.5
  3. XM_017022484.2XP_016877973.1  zinc finger protein 106 isoform X4

  4. XM_005254592.2XP_005254649.1  zinc finger protein 106 isoform X3

    Conserved Domains (5) summary
    pfam09528
    Location:325862
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG2319
    Location:13161744
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:14611738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:15111550
    7WD40; WD40 repeat [structural motif]
  5. XM_017022483.1XP_016877972.1  zinc finger protein 106 isoform X2

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