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ZNF106 zinc finger protein 106 [ Homo sapiens (human) ]

Gene ID: 64397, updated on 23-Nov-2021

Summary

Official Symbol
ZNF106provided by HGNC
Official Full Name
zinc finger protein 106provided by HGNC
Primary source
HGNC:HGNC:12886
See related
Ensembl:ENSG00000103994
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SH3BP3; ZFP106; ZNF474
Expression
Broad expression in heart (RPKM 62.5), fat (RPKM 20.4) and 22 other tissues See more
Orthologs
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Genomic context

See ZNF106 in Genome Data Viewer
Location:
15q15.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (42412823..42491141, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42705021..42783339, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene glucosidase alpha, neutral C Neighboring gene BCL2 interacting protein 3 pseudogene 5 Neighboring gene uncharacterized LOC105370794 Neighboring gene calpain 3 Neighboring gene RNA, U6 small nuclear 188, pseudogene Neighboring gene synaptosome associated protein 23 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ34610, FLJ45841, DKFZp451A239, DKFZp686N20157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 106
Names
SH3-domain binding protein 3
zinc finger protein 474

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284306.2NP_001271235.1  zinc finger protein 106 isoform 2

    See identical proteins and their annotated locations for NP_001271235.1

    Status: REVIEWED

    Source sequence(s)
    AC012651
    Consensus CDS
    CCDS61602.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    UniProtKB/TrEMBL
    A0A0C4DGM5
    Related
    ENSP00000457637.1, ENST00000565611.5
    Conserved Domains (3) summary
    COG2319
    Location:565993
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:710987
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:760799
    7WD40; WD40 repeat [structural motif]
  2. NM_001284307.4NP_001271236.1  zinc finger protein 106 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Consensus CDS
    CCDS61603.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    Related
    ENSP00000455674.1, ENST00000565380.5
    Conserved Domains (3) summary
    COG2319
    Location:6081036
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:7531030
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:803842
    7WD40; WD40 repeat [structural motif]
  3. NM_001366844.3NP_001353773.1  zinc finger protein 106 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Related
    ENSP00000456604.1, ENST00000565500.5
    Conserved Domains (3) summary
    cd00200
    Location:666943
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:716755
    7WD40; WD40 repeat [structural motif]
    pfam09184
    Location:539669
    PPP4R2; PPP4R2
  4. NM_001366845.3NP_001353774.1  zinc finger protein 106 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Related
    ENSP00000456845.2, ENST00000564754.7
    Conserved Domains (3) summary
    cd00200
    Location:15481825
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:15981637
    7WD40; WD40 repeat [structural motif]
  5. NM_001366846.3NP_001353775.1  zinc finger protein 106 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (3) summary
    cd00200
    Location:14611738
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:15111550
    7WD40; WD40 repeat [structural motif]
  6. NM_001381993.1NP_001368922.1  zinc finger protein 106 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:14811758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:15311570
    7WD40; WD40 repeat [structural motif]
  7. NM_001381994.1NP_001368923.1  zinc finger protein 106 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (3) summary
    cd00200
    Location:8201097
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00020
    Location:729
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00039
    Location:870909
    7WD40; WD40 repeat [structural motif]
  8. NM_001381995.1NP_001368924.1  zinc finger protein 106 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:7591036
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:809848
    7WD40; WD40 repeat [structural motif]
  9. NM_001381996.1NP_001368925.1  zinc finger protein 106 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    sd00039
    Location:657691
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:648879
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. NM_001381997.1NP_001368926.1  zinc finger protein 106 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:594871
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:644683
    7WD40; WD40 repeat [structural motif]
  11. NM_001381998.1NP_001368927.1  zinc finger protein 106 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC012651, AC018362
    Conserved Domains (2) summary
    cd00200
    Location:666943
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:716755
    7WD40; WD40 repeat [structural motif]
  12. NM_022473.3NP_071918.1  zinc finger protein 106 isoform 1

    See identical proteins and their annotated locations for NP_071918.1

    Status: REVIEWED

    Source sequence(s)
    AC012651
    Consensus CDS
    CCDS32208.1
    UniProtKB/Swiss-Prot
    Q9H2Y7
    Related
    ENSP00000263805.4, ENST00000263805.8
    Conserved Domains (4) summary
    pfam09528
    Location:302839
    Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
    COG2319
    Location:13801808
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:15251802
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:15751614
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    42412823..42491141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022484.2XP_016877973.1  zinc finger protein 106 isoform X4

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