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TMEM88B transmembrane protein 88B [ Homo sapiens (human) ]

Gene ID: 643965, updated on 8-Dec-2022

Summary

Official Symbol
TMEM88Bprovided by HGNC
Official Full Name
transmembrane protein 88Bprovided by HGNC
Primary source
HGNC:HGNC:37099
See related
Ensembl:ENSG00000205116 AllianceGenome:HGNC:37099
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable PDZ domain binding activity. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 2.6), testis (RPKM 0.2) and 1 other tissue See more
Orthologs
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Genomic context

See TMEM88B in Genome Data Viewer
Location:
1p36.33
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (1425871..1430255)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (857800..864615)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1361251..1365635)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MRPL20 divergent transcript Neighboring gene ANKRD65 antisense RNA 1 Neighboring gene ankyrin repeat domain 65 Neighboring gene long intergenic non-protein coding RNA 1770 Neighboring gene uncharacterized LOC107985729 Neighboring gene Sharpr-MPRA regulatory region 8235 Neighboring gene von Willebrand factor A domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables PDZ domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146685.2NP_001140157.1  transmembrane protein 88B

    See identical proteins and their annotated locations for NP_001140157.1

    Status: VALIDATED

    Source sequence(s)
    AL391244
    Consensus CDS
    CCDS57964.1
    UniProtKB/Swiss-Prot
    A6NKF7
    Related
    ENSP00000455099.1, ENST00000378821.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    1425871..1430255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    857800..864615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)