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GMCL2 germ cell-less 2, spermatogenesis associated [ Homo sapiens (human) ]

Gene ID: 64396, updated on 26-Oct-2022

Summary

Official Symbol
GMCL2provided by HGNC
Official Full Name
germ cell-less 2, spermatogenesis associatedprovided by HGNC
Primary source
HGNC:HGNC:19717
See related
Ensembl:ENSG00000244234 MIM:618629; AllianceGenome:HGNC:19717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCL; GMCL1L; GMCL1P1
Summary
This locus shares a high degree of identity with the multi-exon germ cell-less gene on chromosome 2. Despite its single-exon nature, this chromosome 5 locus contains an open reading frame that could putatively encode a full-length germ cell-less related protein. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See GMCL2 in Genome Data Viewer
Location:
5q35.3
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178184505..178187371, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (178734748..178737614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (177611506..177614372, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene required for meiotic nuclear division 5 homolog B Neighboring gene NAD(P)HX epimerase pseudogene Neighboring gene NHP2 ribonucleoprotein Neighboring gene uncharacterized LOC112267937 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B Neighboring gene 5-phosphohydroxy-L-lysine phospho-lyase Neighboring gene collagen type XXIII alpha 1 chain

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cullin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in germ cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
germ cell-less protein-like 2
Names
germ cell-less protein-like 1-like
germ cell-less related
germ cell-less, spermatogenesis associated 2
putative germ cell-less protein-like 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358008.2NP_001344937.1  germ cell-less protein-like 2

    Status: VALIDATED

    Source sequence(s)
    AC136632, BC033886
    Consensus CDS
    CCDS4433.1
    UniProtKB/Swiss-Prot
    Q8TC89
    Related
    ENSP00000497178.1, ENST00000463439.3
    Conserved Domains (2) summary
    smart00875
    Location:213283
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:98208
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178184505..178187371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    178734748..178737614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_005648.1: Suppressed sequence

    Description
    NG_005648.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.