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RNF222 ring finger protein 222 [ Homo sapiens (human) ]

Gene ID: 643904, updated on 23-Nov-2021

Summary

Official Symbol
RNF222provided by HGNC
Official Full Name
ring finger protein 222provided by HGNC
Primary source
HGNC:HGNC:34517
See related
Ensembl:ENSG00000189051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in esophagus (RPKM 4.4), skin (RPKM 1.4) and 1 other tissue See more
Orthologs
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Genomic context

See RNF222 in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8390702..8397835, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8294020..8301145, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128288 Neighboring gene KRAB-A domain containing 2 Neighboring gene ribosomal protein L26 Neighboring gene Sharpr-MPRA regulatory region 12124 Neighboring gene Sharpr-MPRA regulatory regions 4336 and 10869

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RING finger protein 222
Names
RING finger protein LOC643904

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146684.3NP_001140156.1  RING finger protein 222

    See identical proteins and their annotated locations for NP_001140156.1

    Status: VALIDATED

    Source sequence(s)
    AC026130
    Consensus CDS
    CCDS45608.1
    UniProtKB/Swiss-Prot
    A6NCQ9
    Related
    ENSP00000382330.1, ENST00000399398.2
    Conserved Domains (1) summary
    cd00162
    Location:1368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8390702..8397835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523980.3XP_011522282.1  RING finger protein 222 isoform X1

    See identical proteins and their annotated locations for XP_011522282.1

    UniProtKB/Swiss-Prot
    A6NCQ9
    Conserved Domains (1) summary
    cd00162
    Location:1368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_011523978.3XP_011522280.1  RING finger protein 222 isoform X1

    See identical proteins and their annotated locations for XP_011522280.1

    UniProtKB/Swiss-Prot
    A6NCQ9
    Conserved Domains (1) summary
    cd00162
    Location:1368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_011523979.3XP_011522281.1  RING finger protein 222 isoform X1

    See identical proteins and their annotated locations for XP_011522281.1

    UniProtKB/Swiss-Prot
    A6NCQ9
    Conserved Domains (1) summary
    cd00162
    Location:1368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. XM_011523981.3XP_011522283.1  RING finger protein 222 isoform X1

    See identical proteins and their annotated locations for XP_011522283.1

    UniProtKB/Swiss-Prot
    A6NCQ9
    Conserved Domains (1) summary
    cd00162
    Location:1368
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
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