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MMP25 matrix metallopeptidase 25 [ Homo sapiens (human) ]

Gene ID: 64386, updated on 7-Jun-2020

Summary

Official Symbol
MMP25provided by HGNC
Official Full Name
matrix metallopeptidase 25provided by HGNC
Primary source
HGNC:HGNC:14246
See related
Ensembl:ENSG00000008516 MIM:608482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6
Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 12.9), appendix (RPKM 8.4) and 7 other tissues See more
Orthologs

Genomic context

See MMP25 in Genome Data Viewer
Location:
16p13.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3045963..3060729)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3096682..3110727)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene host cell factor C1 regulator 1 Neighboring gene THO complex 6 Neighboring gene BICD family like cargo adaptor 2 Neighboring gene uncharacterized LOC100128770 Neighboring gene MMP25 antisense RNA 1 Neighboring gene interleukin 32 Neighboring gene RNA, U1 small nuclear 125, pseudogene Neighboring gene uncharacterized LOC107984896

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hard palate development IEA
Inferred from Electronic Annotation
more info
 
inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
matrix metalloproteinase-25
Names
leukolysin
matrix metallopeptidase-like 1
matrix metalloproteinase 20
matrix metalloproteinase-like 1
membrane-type 6 matrix metalloproteinase
membrane-type matrix metalloproteinase 6

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022468.5NP_071913.1  matrix metalloproteinase-25 preproprotein

    See identical proteins and their annotated locations for NP_071913.1

    Status: REVIEWED

    Source sequence(s)
    AC108134, AJ272137, CB529891
    Consensus CDS
    CCDS10492.1
    UniProtKB/Swiss-Prot
    Q9NPA2
    Related
    ENSP00000337816.4, ENST00000336577.9
    Conserved Domains (4) summary
    cd00094
    Location:314508
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:115280
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:115280
    Peptidase_M10; Matrixin
    pfam01471
    Location:2585
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3045963..3060729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450390.1XP_024306158.1  matrix metalloproteinase-25 isoform X1

    Conserved Domains (3) summary
    cd00094
    Location:171365
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam01471
    Location:2580
    PG_binding_1; Putative peptidoglycan binding domain
    cl00064
    Location:78137
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
  2. XM_017023561.1XP_016879050.1  matrix metalloproteinase-25 isoform X4

  3. XM_024450391.1XP_024306159.1  matrix metalloproteinase-25 isoform X2

    Conserved Domains (2) summary
    cd00094
    Location:280474
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:81246
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
  4. XM_011522604.2XP_011520906.1  matrix metalloproteinase-25 isoform X3

    Conserved Domains (3) summary
    cd00094
    Location:230424
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:31196
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:31196
    Peptidase_M10; Matrixin
  5. XM_011522605.2XP_011520907.1  matrix metalloproteinase-25 isoform X5

    See identical proteins and their annotated locations for XP_011520907.1

    Conserved Domains (3) summary
    cd00094
    Location:104298
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:870
    Peptidase_M10; Matrixin
    cl00064
    Location:1170
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004142.1: Suppressed sequence

    Description
    NM_004142.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NM_022718.2: Suppressed sequence

    Description
    NM_022718.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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