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TMPPE transmembrane protein with metallophosphoesterase domain [ Homo sapiens (human) ]

Gene ID: 643853, updated on 6-Nov-2022

Summary

Official Symbol
TMPPEprovided by HGNC
Official Full Name
transmembrane protein with metallophosphoesterase domainprovided by HGNC
Primary source
HGNC:HGNC:33865
See related
Ensembl:ENSG00000188167 AllianceGenome:HGNC:33865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable hydrolase activity and metal ion binding activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 2.1), appendix (RPKM 1.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMPPE in Genome Data Viewer
Location:
3p22.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (33090422..33097146, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (33092195..33098917, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (33131914..33138638, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene galactosidase beta 1 Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component pseudogene 1 Neighboring gene SUMO2 pseudogene 10 Neighboring gene RNA, 7SL, cytoplasmic 296, pseudogene Neighboring gene cartilage associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45032, FLJ46376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein with metallophosphoesterase domain
NP_001034859.2
NP_001129710.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039770.3NP_001034859.2  transmembrane protein with metallophosphoesterase domain isoform 1

    See identical proteins and their annotated locations for NP_001034859.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC112211, AK126979, AK128242, BC136872
    Consensus CDS
    CCDS33732.1
    UniProtKB/Swiss-Prot
    Q6ZRG1, Q6ZT21
    Related
    ENSP00000343398.4, ENST00000342462.5
    Conserved Domains (1) summary
    cd07385
    Location:206449
    MPP_YkuE_C; Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain
  2. NM_001136238.2NP_001129710.1  transmembrane protein with metallophosphoesterase domain isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different acceptor splice site at the 3' terminal exon compared to transcript variant 1. This results in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AC112211, AK126979, AK128242
    Consensus CDS
    CCDS46786.1
    UniProtKB/Swiss-Prot
    Q6ZT21
    Related
    ENSP00000400715.2, ENST00000416695.6
    Conserved Domains (2) summary
    cd07385
    Location:69312
    MPP_YkuE_C; Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain
    pfam00149
    Location:70256
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    33090422..33097146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    33092195..33098917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)