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PGA4 pepsinogen A4 [ Homo sapiens (human) ]

Gene ID: 643847, updated on 5-Jan-2022

Summary

Official Symbol
PGA4provided by HGNC
Official Full Name
pepsinogen A4provided by HGNC
Primary source
HGNC:HGNC:8886
See related
Ensembl:ENSG00000229183 MIM:169720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward stomach (RPKM 23688.7) See more
Orthologs
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Genomic context

See PGA4 in Genome Data Viewer
Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61222347..61231694)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60989819..60999166)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VPS37C subunit of ESCRT-I Neighboring gene pepsinogen A3 Neighboring gene pepsinogen A5 Neighboring gene von Willebrand factor C and EGF domains

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ58952, FLJ77962

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pepsin A-4
Names
pepsinogen 4, group I (pepsinogen A)
pepsinogen-4
pregnancy-associated glycoprotein
NP_001073276.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079808.6NP_001073276.1  pepsin A-4 preproprotein

    See identical proteins and their annotated locations for NP_001073276.1

    Status: REVIEWED

    Source sequence(s)
    AP000437, AP003037
    Consensus CDS
    CCDS31575.1
    UniProtKB/Swiss-Prot
    P0DJD7
    UniProtKB/TrEMBL
    A0A1S5UZ02, B7Z719
    Related
    ENSP00000367391.3, ENST00000378149.9
    Conserved Domains (2) summary
    cd05478
    Location:66386
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam07966
    Location:1745
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61222347..61231694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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