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ZFP62 ZFP62 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 643836, updated on 5-Aug-2022

Summary

Official Symbol
ZFP62provided by HGNC
Official Full Name
ZFP62 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:23241
See related
Ensembl:ENSG00000196670 MIM:610281; AllianceGenome:HGNC:23241
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZET; ZNF755
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: Annotation of ZFP62 was placed on AC016572.6 on NCBI's annotation 36.3. This clone has been determined to be redundant, so the annotation was merged with the location on the assembled chromosome. [02 Mar 2009]
Expression
Ubiquitous expression in thyroid (RPKM 6.7), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZFP62 in Genome Data Viewer
Location:
5q35.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180826870..180861276, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181403940..181417610, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180274611..180288276, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase Neighboring gene Sharpr-MPRA regulatory region 14850 Neighboring gene long intergenic non-protein coding RNA 847 Neighboring gene Sharpr-MPRA regulatory region 9005 Neighboring gene hepatocellular carcinoma up-regulated EZH2-associated long non-coding RNA Neighboring gene uncharacterized LOC124901155 Neighboring gene butyrophilin like 8 Neighboring gene ribosomal protein S29 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11344, FLJ34057, FLJ34231, FLJ58781, FLJ59694, MGC176438, DKFZp667F2013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 62 homolog
Names
zfp-62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172638.2NP_001166109.1  zinc finger protein 62 homolog isoform 2

    See identical proteins and their annotated locations for NP_001166109.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS54955.1
    UniProtKB/Swiss-Prot
    J3QTA9, Q8NB50
    Related
    ENSP00000423820.1, ENST00000502412.2
    Conserved Domains (2) summary
    COG5048
    Location:447860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001377939.1NP_001364868.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001377940.1NP_001364869.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001377941.1NP_001364870.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001377942.1NP_001364871.1  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001377943.1NP_001364872.1  zinc finger protein 62 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022413
    UniProtKB/Swiss-Prot
    J3QTA9
    Conserved Domains (2) summary
    COG5048
    Location:447860
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001377944.1NP_001364873.1  zinc finger protein 62 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:363776
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001377945.1NP_001364874.1  zinc finger protein 62 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC022413
    Conserved Domains (2) summary
    COG5048
    Location:330743
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_152283.5NP_689496.4  zinc finger protein 62 homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC022413
    Consensus CDS
    CCDS47357.2
    UniProtKB/Swiss-Prot
    Q8NB50
    Related
    ENSP00000426193.1, ENST00000512132.5
    Conserved Domains (2) summary
    COG5048
    Location:414827
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:194214
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    180826870..180861276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417504.1XP_047273460.1  zinc finger protein 62 homolog isoform X9

  2. XM_047417501.1XP_047273457.1  zinc finger protein 62 homolog isoform X5

  3. XM_047417502.1XP_047273458.1  zinc finger protein 62 homolog isoform X7

  4. XM_017009716.3XP_016865205.1  zinc finger protein 62 homolog isoform X3

  5. XM_017009718.3XP_016865207.1  zinc finger protein 62 homolog isoform X4

  6. XM_047417499.1XP_047273455.1  zinc finger protein 62 homolog isoform X1

  7. XM_047417500.1XP_047273456.1  zinc finger protein 62 homolog isoform X2

  8. XM_047417503.1XP_047273459.1  zinc finger protein 62 homolog isoform X8

  9. XM_017009719.3XP_016865208.1  zinc finger protein 62 homolog isoform X6

RNA

  1. XR_007058623.1 RNA Sequence

  2. XR_007058622.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    181403940..181417610 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)