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PGA3 pepsinogen 3, group I (pepsinogen A) [ Homo sapiens (human) ]

Gene ID: 643834, updated on 17-Jun-2019

Summary

Official Symbol
PGA3provided by HGNC
Official Full Name
pepsinogen 3, group I (pepsinogen A)provided by HGNC
Primary source
HGNC:HGNC:8885
See related
Ensembl:ENSG00000229859 MIM:169710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward stomach (RPKM 21519.3) See more
Orthologs

Genomic context

See PGA3 in Genome Data Viewer
Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61203515..61213098)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60970984..60980350)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3147/8872 Neighboring gene VPS37C subunit of ESCRT-I Neighboring gene pepsinogen 4, group I (pepsinogen A) Neighboring gene pepsinogen 5, group I (pepsinogen A)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...

General gene information

Markers

Homology

Clone Names

  • DKFZp666J2410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
digestion IEA
Inferred from Electronic Annotation
more info
 
protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
multivesicular body lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
pepsin A-3
Names
pepsinogen A3
pepsinogen-3
NP_001073275.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079807.4NP_001073275.1  pepsin A-3 preproprotein

    See identical proteins and their annotated locations for NP_001073275.1

    Status: REVIEWED

    Source sequence(s)
    AK225679, AK312941, AP000437
    Consensus CDS
    CCDS31574.1
    UniProtKB/Swiss-Prot
    P0DJD8
    Related
    ENSP00000322192.6, ENST00000325558.10
    Conserved Domains (3) summary
    cd05478
    Location:66386
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam00026
    Location:75387
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:1745
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61203515..61213098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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