U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PGA3 pepsinogen A3 [ Homo sapiens (human) ]

Gene ID: 643834, updated on 5-Aug-2022

Summary

Official Symbol
PGA3provided by HGNC
Official Full Name
pepsinogen A3provided by HGNC
Primary source
HGNC:HGNC:8885
See related
Ensembl:ENSG00000229859 MIM:169710; AllianceGenome:HGNC:8885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Expression
Restricted expression toward stomach (RPKM 21519.3) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PGA3 in Genome Data Viewer
Location:
11q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61203515..61213098)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61155047..61164627)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60970987..60980570)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene VPS37C subunit of ESCRT-I Neighboring gene uncharacterized LOC124902678 Neighboring gene pepsinogen A4 Neighboring gene pepsinogen A5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp666J2410

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in digestion IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pepsin A-3
Names
pepsinogen 3, group I (pepsinogen A)
pepsinogen-3
NP_001073275.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079807.4NP_001073275.1  pepsin A-3 preproprotein

    See identical proteins and their annotated locations for NP_001073275.1

    Status: REVIEWED

    Source sequence(s)
    AK225679, AK312941, AP000437
    Consensus CDS
    CCDS31574.1
    UniProtKB/Swiss-Prot
    P0DJD8, Q8N1E3
    Related
    ENSP00000322192.6, ENST00000325558.11
    Conserved Domains (3) summary
    cd05478
    Location:66386
    pepsin_A; Pepsin A, aspartic protease produced in gastric mucosa of mammals
    pfam00026
    Location:75387
    Asp; Eukaryotic aspartyl protease
    pfam07966
    Location:1745
    A1_Propeptide; A1 Propeptide

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61203515..61213098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61155047..61164627
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)