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CHST8 carbohydrate sulfotransferase 8 [ Homo sapiens (human) ]

Gene ID: 64377, updated on 11-Sep-2019

Summary

Official Symbol
CHST8provided by HGNC
Official Full Name
carbohydrate sulfotransferase 8provided by HGNC
Primary source
HGNC:HGNC:15993
See related
Ensembl:ENSG00000124302 MIM:610190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSS3; GalNAc4ST; GALNAC4ST1
Summary
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See CHST8 in Genome Data Viewer
Location:
19q13.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (33621953..33773509)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (34112861..34264414)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996681 Neighboring gene ribosomal protein L21 pseudogene 131 Neighboring gene potassium channel tetramerization domain containing 15 Neighboring gene RNA, 7SL, cytoplasmic 150, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Peeling skin syndrome 3
MedGen: C4015729 OMIM: 616265 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
NHGRI GWA Catalog
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylgalactosamine 4-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylgalactosamine 4-O-sulfotransferase activity TAS
Traceable Author Statement
more info
 
sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
hormone biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
carbohydrate sulfotransferase 8
Names
GALNAC-4-ST1
GalNAc-4-O-sulfotransferase 1
N-acetylgalactosamine-4-O-sulfotransferase 1
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
galNAc4ST-1
NP_001121367.1
NP_001121368.1
NP_071912.2
XP_011525524.1
XP_011525526.1
XP_016882632.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029857.1 RefSeqGene

    Range
    4999..156551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127895.2NP_001121367.1  carbohydrate sulfotransferase 8

    See identical proteins and their annotated locations for NP_001121367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC010510, BC011380, BC014250, BX354555, DB500322
    Consensus CDS
    CCDS12433.1
    UniProtKB/Swiss-Prot
    Q9H2A9
    Related
    ENSP00000499084.1, ENST00000650847.1
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family
  2. NM_001127896.2NP_001121368.1  carbohydrate sulfotransferase 8

    See identical proteins and their annotated locations for NP_001121368.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC010510, BC014250, BI917117
    Consensus CDS
    CCDS12433.1
    UniProtKB/Swiss-Prot
    Q9H2A9
    Related
    ENSP00000393879.1, ENST00000438847.7
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family
  3. NM_022467.3NP_071912.2  carbohydrate sulfotransferase 8

    See identical proteins and their annotated locations for NP_071912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' non-coding exon compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC018723
    Consensus CDS
    CCDS12433.1
    UniProtKB/Swiss-Prot
    Q9H2A9
    Related
    ENSP00000262622.3, ENST00000262622.4
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    33621953..33773509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527224.1XP_011525526.1  carbohydrate sulfotransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_011525526.1

    UniProtKB/Swiss-Prot
    Q9H2A9
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family
  2. XM_011527222.1XP_011525524.1  carbohydrate sulfotransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_011525524.1

    UniProtKB/Swiss-Prot
    Q9H2A9
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family
  3. XM_017027143.1XP_016882632.1  carbohydrate sulfotransferase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q9H2A9
    Conserved Domains (1) summary
    pfam03567
    Location:187416
    Sulfotransfer_2; Sulfotransferase family
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