Format

Send to:

Choose Destination

IKZF5 IKAROS family zinc finger 5 [ Homo sapiens (human) ]

Gene ID: 64376, updated on 1-Aug-2020

Summary

Official Symbol
IKZF5provided by HGNC
Official Full Name
IKAROS family zinc finger 5provided by HGNC
Primary source
HGNC:HGNC:14283
See related
Ensembl:ENSG00000095574 MIM:606238
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEGASUS; ZNFN1A5
Summary
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Expression
Ubiquitous expression in bone marrow (RPKM 13.4), testis (RPKM 7.5) and 25 other tissues See more
Orthologs

Genomic context

See IKZF5 in Genome Data Viewer
Location:
10q26.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (122990806..123008826, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124750322..124768366, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene chromosome 10 open reading frame 88 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene acyl-CoA dehydrogenase short/branched chain Neighboring gene VISTA enhancer hs1319

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13226, FLJ22973, FLJ30945, DKFZp781B0249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
zinc finger protein Pegasus
Names
zinc finger protein, subfamily 1A, 5 (Pegasus)
zinc finger transcription factor Pegasus

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_067239.1 RefSeqGene

    Range
    5001..22989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1429

mRNA and Protein(s)

  1. NM_001271840.1NP_001258769.1  zinc finger protein Pegasus isoform 1

    See identical proteins and their annotated locations for NP_001258769.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC073585, AI560579, DA218215
    Consensus CDS
    CCDS41574.1
    UniProtKB/Swiss-Prot
    Q9H5V7
    Related
    ENSP00000478056.1, ENST00000617859.4
    Conserved Domains (3) summary
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:124148
    zf-H2C2_2; Zinc-finger double domain
    cl28111
    Location:251361
    Marek_A; Marek's disease glycoprotein A
  2. NM_001372123.1NP_001359052.1  zinc finger protein Pegasus isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073585
    Related
    ENSP00000357881.5, ENST00000368886.9
  3. NM_001372124.1NP_001359053.1  zinc finger protein Pegasus isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073585
  4. NM_001372125.1NP_001359054.1  zinc finger protein Pegasus isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073585
  5. NM_001372126.1NP_001359055.1  zinc finger protein Pegasus isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073585
  6. NM_001372127.1NP_001359056.1  zinc finger protein Pegasus isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073585
  7. NM_001372128.1NP_001359057.1  zinc finger protein Pegasus isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC073585
  8. NM_001372129.1NP_001359058.1  zinc finger protein Pegasus isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073585
  9. NM_001372130.1NP_001359059.1  zinc finger protein Pegasus isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073585
  10. NM_001372131.1NP_001359060.1  zinc finger protein Pegasus isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC073585

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    122990806..123008826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016551.2XP_016872040.1  zinc finger protein Pegasus isoform X1

    UniProtKB/Swiss-Prot
    Q9H5V7
    Conserved Domains (3) summary
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:124148
    zf-H2C2_2; Zinc-finger double domain
    cl28111
    Location:251361
    Marek_A; Marek's disease glycoprotein A
  2. XM_006717947.4XP_006718010.1  zinc finger protein Pegasus isoform X1

    See identical proteins and their annotated locations for XP_006718010.1

    UniProtKB/Swiss-Prot
    Q9H5V7
    Conserved Domains (3) summary
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:124148
    zf-H2C2_2; Zinc-finger double domain
    cl28111
    Location:251361
    Marek_A; Marek's disease glycoprotein A

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_073476.2: Suppressed sequence

    Description
    NR_073476.2: This RefSeq was removed because it is now thought that this transcript does encode a protein.
Support Center