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ZNF862 zinc finger protein 862 [ Homo sapiens (human) ]

Gene ID: 643641, updated on 10-Dec-2024

Summary

Official Symbol
ZNF862provided by HGNC
Official Full Name
zinc finger protein 862provided by HGNC
Primary source
HGNC:HGNC:34519
See related
Ensembl:ENSG00000106479 MIM:620974; AllianceGenome:HGNC:34519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GINGF6
Summary
Predicted to enable metal ion binding activity and protein dimerization activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in skin (RPKM 4.4), thyroid (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF862 in Genome Data Viewer
Location:
7q36.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149838375..149867479)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151020282..151049591)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149535464..149564568)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149438995-149439524 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149463303-149463978 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149479128-149479704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149480282-149480858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149480859-149481434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149482621-149483120 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149484857-149485446 Neighboring gene Sharpr-MPRA regulatory region 4172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149487626-149488414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149496913-149497414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149497415-149497914 Neighboring gene zinc finger protein 467 Neighboring gene SCO-spondin, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552405-149552958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149552959-149553510 Neighboring gene ATP6V0E2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149570857-149571825 Neighboring gene ATPase H+ transporting V0 subunit e2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:149604113-149604612 Neighboring gene actin related protein 3C Neighboring gene uncharacterized LOC124901772

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30362, KIAA0543

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051961.1 RefSeqGene

    Range
    4410..33514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001099220.3NP_001092690.1  zinc finger protein 862

    See identical proteins and their annotated locations for NP_001092690.1

    Status: VALIDATED

    Source sequence(s)
    AB011115, AC004877, BC113087, BQ270712, BU164247, DA724031
    Consensus CDS
    CCDS47741.1
    UniProtKB/Swiss-Prot
    A0AUL8, O60290
    Related
    ENSP00000223210.4, ENST00000223210.5
    Conserved Domains (5) summary
    cd07765
    Location:1141
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:333393
    KRAB; krueppel associated box
    smart00597
    Location:135218
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam01352
    Location:333372
    KRAB; KRAB box
    pfam05699
    Location:9901066
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149838375..149867479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516464.2XP_011514766.1  zinc finger protein 862 isoform X2

    Conserved Domains (5) summary
    cd07765
    Location:1848
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:340400
    KRAB; krueppel associated box
    smart00597
    Location:142225
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam01352
    Location:340379
    KRAB; KRAB box
    pfam05699
    Location:9971073
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
  2. XM_017012519.2XP_016868008.1  zinc finger protein 862 isoform X3

  3. XM_024446866.1XP_024302634.1  zinc finger protein 862 isoform X4

    Conserved Domains (3) summary
    smart00349
    Location:249309
    KRAB; krueppel associated box
    smart00597
    Location:51134
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:906982
    Dimer_Tnp_hAT; hAT family C-terminal dimerisation region
  4. XM_006716085.4XP_006716148.1  zinc finger protein 862 isoform X1

    See identical proteins and their annotated locations for XP_006716148.1

    Conserved Domains (5) summary
    cd07765
    Location:2555
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:347407
    KRAB; krueppel associated box
    smart00597
    Location:149232
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam01352
    Location:347386
    KRAB; KRAB box
    pfam05699
    Location:10041080
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
  5. XM_011516463.1XP_011514765.1  zinc finger protein 862 isoform X1

    See identical proteins and their annotated locations for XP_011514765.1

    Conserved Domains (5) summary
    cd07765
    Location:2555
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:347407
    KRAB; krueppel associated box
    smart00597
    Location:149232
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam01352
    Location:347386
    KRAB; KRAB box
    pfam05699
    Location:10041080
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
  6. XM_011516465.3XP_011514767.1  zinc finger protein 862 isoform X5

    Conserved Domains (2) summary
    smart00597
    Location:137220
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:666742
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region
  7. XM_011516466.3XP_011514768.1  zinc finger protein 862 isoform X6

    Conserved Domains (2) summary
    smart00597
    Location:50133
    ZnF_TTF; zinc finger in transposases and transcription factors
    pfam05699
    Location:579655
    Dimer_Tnp_hAT; hAT family C-terminal dimerization region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151020282..151049591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)