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Des desmin [ Rattus norvegicus (Norway rat) ]

Gene ID: 64362, updated on 21-Jul-2018

Summary

Official Symbol
Desprovided by RGD
Official Full Name
desminprovided by RGD
Primary source
RGD:620686
See related
Ensembl:ENSRNOG00000019810
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
class II intermediate filament protein, localized to muscle cells, may be a differentiation marker for muscle cells [RGD, Feb 2006]
Expression
Biased expression in Muscle (RPKM 8191.8), Heart (RPKM 4982.5) and 2 other tissues See more
Orthologs

Genomic context

See Des in Genome Data Viewer
Location:
9q33
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82556574..82564288)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 9 NC_005108.3 (82325835..82333549)

Chromosome 9 - NC_005108.4Genomic Context describing neighboring genes Neighboring gene regulated endocrine-specific protein 18 Neighboring gene aspartyl aminopeptidase Neighboring gene uncharacterized LOC102550477 Neighboring gene striated muscle enriched protein kinase Neighboring gene uncharacterized LOC108351955 Neighboring gene GDP-mannose pyrophosphorylase A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intermediate filament organization IEA
Inferred from Electronic Annotation
more info
 
intermediate filament organization ISO
Inferred from Sequence Orthology
more info
 
intermediate filament organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
Z disc IEA
Inferred from Electronic Annotation
more info
 
Z disc ISO
Inferred from Sequence Orthology
more info
 
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac myofibril IEA
Inferred from Electronic Annotation
more info
 
cardiac myofibril ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
contractile fiber ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
fascia adherens IEA
Inferred from Electronic Annotation
more info
 
fascia adherens ISO
Inferred from Sequence Orthology
more info
 
gap junction IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc ISO
Inferred from Sequence Orthology
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with intermediate filament ISO
Inferred from Sequence Orthology
more info
 
intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
sarcolemma ISO
Inferred from Sequence Orthology
more info
 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
type III intermediate filament IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022531.1NP_071976.1  desmin

    See identical proteins and their annotated locations for NP_071976.1

    Status: PROVISIONAL

    Source sequence(s)
    X73524
    UniProtKB/Swiss-Prot
    P48675
    Related
    ENSRNOP00000026860.3, ENSRNOT00000026860.4
    Conserved Domains (2) summary
    pfam00038
    Location:106414
    Filament; Intermediate filament protein
    pfam04732
    Location:9105
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005108.4 Reference Rnor_6.0 Primary Assembly

    Range
    82556574..82564288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000077.1 Alternate Rn_Celera

    Range
    74421090..74428604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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