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Lsr lipolysis stimulated lipoprotein receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 64355, updated on 30-May-2026
Official Symbol
Lsrprovided by RGD
Official Full Name
lipolysis stimulated lipoprotein receptorprovided by RGD
Primary source
RGD:69236
See related
Ensembl:ENSRNOG00000021053 AllianceGenome:RGD:69236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lisch7
Summary
Predicted to enable fatty acid binding activity and triglyceride binding activity. Involved in regulation of lipid metabolic process. Predicted to be located in tight junction. Predicted to be part of chylomicron; low-density lipoprotein particle; and very-low-density lipoprotein particle. Predicted to be active in plasma membrane and tricellular tight junction. Orthologous to human LSR (lipolysis stimulated lipoprotein receptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 220.7), Kidney (RPKM 131.0) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Lsr in Genome Data Viewer
Location:
1q21
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (95313830..95329471, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (86185769..86201952, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (89383515..89399041, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099789 Neighboring gene myelin-associated glycoprotein Neighboring gene hepcidin antimicrobial peptide Neighboring gene upstream transcription factor 2, c-fos interacting Neighboring gene family with sequence similarity 187, member B Neighboring gene uncharacterized LOC134483094 Neighboring gene uncharacterized LOC134483095

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis. Wang J, et al. Biomed Res Int, 2022. PMID 35463981, Free PMC Article
  2. Lipolysis-stimulated lipoprotein receptor: a novel membrane protein of tricellular tight junctions. Furuse M, et al. Ann N Y Acad Sci, 2012 Jun. PMID 22671589
  3. Molecular cloning of a lipolysis-stimulated remnant receptor expressed in the liver. Yen FT, et al. J Biol Chem, 1999 May 7. PMID 10224102
  4. LSR/angulin-1 is a tricellular tight junction protein involved in blood-brain barrier formation. Sohet F, et al. J Cell Biol, 2015 Mar 16. PMID 25753034, Free PMC Article
  5. LSR defines cell corners for tricellular tight junction formation in epithelial cells. Masuda S, et al. J Cell Sci, 2011 Feb 15. PMID 21245199

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis.
    Title: Effects of Lipolysis-Stimulated Lipoprotein Receptor on Tight Junctions of Pancreatic Ductal Epithelial Cells in Hypertriglyceridemic Acute Pancreatitis.
Submit: New GeneRIF Correction

Markers

Homology

Clone Names

  • MGC124592

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fatty acid binding TAS
Traceable Author Statement
more info
 PubMed 
enables triglyceride binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in epithelial structure maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial structure maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial structure maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of blood-brain barrier IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of blood-brain barrier IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of skin barrier IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to tricellular tight junction IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to tricellular tight junction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in tricellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in tricellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in tricellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in tricellular tight junction ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
lipolysis-stimulated lipoprotein receptor
Names
lipolysis-stimulated receptor
lipolysis-stimulated remnant receptor
liver-specific bHLH-Zip transcription factor 7

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001438371.1 → NP_001425300.1  lipolysis-stimulated lipoprotein receptor isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GKQ0, A6JA41

  2. NM_001438372.1 → NP_001425301.1  lipolysis-stimulated lipoprotein receptor isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GKQ0, A6JA40

  3. NM_032616.3 → NP_116005.1  lipolysis-stimulated lipoprotein receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_116005.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q497B9, Q9WU74, Q9WU75, Q9WU76
    UniProtKB/TrEMBL
    A0ABK0MAN1, A6JA42
    Related
    ENSRNOP00000041379.2, ENSRNOT00000044678.7
    Conserved Domains (1) summary
    pfam12871
    Location:470 → 531
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    95313830..95329471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228845.5 → XP_006228907.1  

    Related
    ENSRNOP00000097477.1, ENSRNOT00000116572.2
    Conserved Domains (1) summary
    pfam12871
    Location:402 → 463
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term

  2. XM_006228844.5 → XP_006228906.1  

    Related
    ENSRNOP00000028585.4, ENSRNOT00000028585.9
    Conserved Domains (2) summary
    pfam08648
    Location:451 → 512
    DUF1777; Protein of unknown function (DUF1777)
    pfam12871
    Location:451 → 512
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU74.1 GenPept UniProtKB/Swiss-Prot:Q9WU74

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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