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Htr6 5-hydroxytryptamine receptor 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64354, updated on 4-Nov-2022

Summary

Official Symbol
Htr6provided by RGD
Official Full Name
5-hydroxytryptamine receptor 6provided by RGD
Primary source
RGD:62044
See related
Ensembl:ENSRNOG00000049761 AllianceGenome:RGD:62044
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 8.2) See more
Orthologs
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Genomic context

See Htr6 in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151295269..151312853, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157501202..157518870, complement)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 186 Neighboring gene transmembrane and coiled-coil domains 4 Neighboring gene uncharacterized LOC120103015 Neighboring gene NBL1, DAN family BMP antagonist Neighboring gene mitochondrial contact site and cristae organizing system subunit 10 Neighboring gene uncharacterized LOC120103016

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebral cortex cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in learning IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of glutamate secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 6
Names
5-HT-6
5-HT6
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
ST-B17
serotonin receptor 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024365.2NP_077341.2  5-hydroxytryptamine receptor 6

    See identical proteins and their annotated locations for NP_077341.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000162
    UniProtKB/TrEMBL
    A0A8L2QXZ5
    Related
    ENSRNOP00000064366.3, ENSRNOT00000070865.3
    Conserved Domains (1) summary
    pfam00001
    Location:44320
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    151295269..151312853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593608.2XP_017449097.1  5-hydroxytryptamine receptor 6 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QXZ5
    Conserved Domains (1) summary
    pfam00001
    Location:44320
    7tm_1; 7 transmembrane receptor (rhodopsin family)