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LIPK lipase family member K [ Homo sapiens (human) ]

Gene ID: 643414, updated on 5-Jan-2022

Summary

Official Symbol
LIPKprovided by HGNC
Official Full Name
lipase family member Kprovided by HGNC
Primary source
HGNC:HGNC:23444
See related
Ensembl:ENSG00000204021 MIM:613922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL2; bA186O14.2
Summary
Predicted to enable lipoprotein lipase activity. Predicted to be involved in cornification. Predicted to be located in extracellular region. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Restricted expression toward skin (RPKM 5.3) See more
Orthologs
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Genomic context

See LIPK in Genome Data Viewer
Location:
10q23.31
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (88706225..88753092)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90466006..90512533)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase F, gastric type Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1 Neighboring gene keratin 8 pseudogene 38 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipoprotein lipase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cornification TAS
Traceable Author Statement
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lipase member K
Names
lipase K
lipase-like abhydrolase domain-containing protein 2
lipase-like, ab-hydrolase domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080518.2NP_001073987.1  lipase member K isoform 1 precursor

    See identical proteins and their annotated locations for NP_001073987.1

    Status: VALIDATED

    Source sequence(s)
    AL358532
    Consensus CDS
    CCDS44455.1
    UniProtKB/Swiss-Prot
    Q5VXJ0
    Related
    ENSP00000383900.1, ENST00000404190.3
    Conserved Domains (3) summary
    PLN02872
    Location:11390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3597
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:79226
    Abhydrolase_5; Alpha/beta hydrolase family
  2. NM_001378091.1NP_001365020.1  lipase member K isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL358532
    Conserved Domains (1) summary
    PLN02872
    Location:11357
    PLN02872; triacylglycerol lipase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    88706225..88753092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016548.2XP_016872037.1  lipase member K isoform X7

  2. XM_017016545.1XP_016872034.1  lipase member K isoform X4

  3. XM_017016547.2XP_016872036.1  lipase member K isoform X6

  4. XM_017016546.2XP_016872035.1  lipase member K isoform X5

  5. XM_011540073.3XP_011538375.1  lipase member K isoform X1

    Conserved Domains (3) summary
    PLN02872
    Location:31410
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:55117
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:99246
    Abhydrolase_5; Alpha/beta hydrolase family
  6. XM_011540075.1XP_011538377.1  lipase member K isoform X2

    Conserved Domains (3) summary
    PLN02872
    Location:20399
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:44106
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:88235
    Abhydrolase_5; Alpha/beta hydrolase family
  7. XM_011540082.1XP_011538384.1  lipase member K isoform X8

    Conserved Domains (1) summary
    PLN02872
    Location:7256
    PLN02872; triacylglycerol lipase

RNA

  1. XR_001747184.2 RNA Sequence

  2. XR_001747183.2 RNA Sequence

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