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LIPK lipase family member K [ Homo sapiens (human) ]

Gene ID: 643414, updated on 23-May-2018

Summary

Official Symbol
LIPKprovided by HGNC
Official Full Name
lipase family member Kprovided by HGNC
Primary source
HGNC:HGNC:23444
See related
Ensembl:ENSG00000204021 MIM:613922; Vega:OTTHUMG00000018693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIPL2; bA186O14.2
Expression
Restricted expression toward skin (RPKM 5.3) See more
Orthologs

Genomic context

See LIPK in Genome Data Viewer
Location:
10q23.31
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (88706225..88753092)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90484301..90512513)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene lipase F, gastric type Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1 Neighboring gene keratin 8 pseudogene 38 Neighboring gene lipase family member N Neighboring gene RCC1 and BTB domain containing protein 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Digestion of dietary lipid, organism-specific biosystem (from REACTOME)
    Digestion of dietary lipid, organism-specific biosystemDietary lipids such as long-chain triacylglycerols and cholesterol esters are digested in the stomach and small intestine to yield long-chain fatty acids, monoacylglycerols, glycerol and cholesterol ...
  • Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
    Lipid digestion, mobilization, and transport, organism-specific biosystemProcesses annotated here include the digestion of dietary lipids, sterol uptake, the formation and turnover of lipoproteins (chylomicrons, VLDL, LDL, and HDL), and the mobilization of fatty acids thr...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipoprotein lipase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cornification TAS
Traceable Author Statement
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lipase member K
Names
lipase K
lipase-like abhydrolase domain-containing protein 2
lipase-like, ab-hydrolase domain containing 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080518.1NP_001073987.1  lipase member K precursor

    See identical proteins and their annotated locations for NP_001073987.1

    Status: VALIDATED

    Source sequence(s)
    EF426482
    Consensus CDS
    CCDS44455.1
    UniProtKB/Swiss-Prot
    Q5VXJ0
    Related
    ENSP00000383900.1, OTTHUMP00000020036, ENST00000404190.1, OTTHUMT00000049253
    Conserved Domains (3) summary
    PLN02872
    Location:11390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3597
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:79226
    Abhydrolase_5; Alpha/beta hydrolase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    88706225..88753092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016548.2XP_016872037.1  lipase member K isoform X7

  2. XM_017016545.1XP_016872034.1  lipase member K isoform X4

  3. XM_017016547.2XP_016872036.1  lipase member K isoform X6

  4. XM_017016546.2XP_016872035.1  lipase member K isoform X5

  5. XM_011540073.3XP_011538375.1  lipase member K isoform X1

    Conserved Domains (3) summary
    PLN02872
    Location:31410
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:55117
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:99246
    Abhydrolase_5; Alpha/beta hydrolase family
  6. XM_011540075.1XP_011538377.1  lipase member K isoform X2

    Conserved Domains (3) summary
    PLN02872
    Location:20399
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:44106
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:88235
    Abhydrolase_5; Alpha/beta hydrolase family
  7. XM_011540077.1XP_011538379.1  lipase member K isoform X3

    See identical proteins and their annotated locations for XP_011538379.1

    UniProtKB/Swiss-Prot
    Q5VXJ0
    Conserved Domains (3) summary
    PLN02872
    Location:11390
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:3597
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:79226
    Abhydrolase_5; Alpha/beta hydrolase family
  8. XM_011540082.1XP_011538384.1  lipase member K isoform X8

    Conserved Domains (1) summary
    PLN02872
    Location:7256
    PLN02872; triacylglycerol lipase

RNA

  1. XR_001747184.2 RNA Sequence

  2. XR_001747183.2 RNA Sequence

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