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SPINK9 serine peptidase inhibitor Kazal type 9 [ Homo sapiens (human) ]

Gene ID: 643394, updated on 24-Nov-2020

Summary

Official Symbol
SPINK9provided by HGNC
Official Full Name
serine peptidase inhibitor Kazal type 9provided by HGNC
Primary source
HGNC:HGNC:32951
See related
Ensembl:ENSG00000204909 MIM:613511
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEKTI2
Summary
The protein encoded by this gene is a Kazal-type serine protease inhibitor that appears to specifically target kallikrein-related peptidase 5 (KLK5) in the palmo-plantar epidermis. KLK5 is an important initiator of skin desquamation, so the encoded protease inhibitor may regulate skin differentiation in the palms of hands and soles of feet. This cationic protein has also been shown to promote keratinocyte migration by activation of the epidermal growth factor receptor (EGFR). [provided by RefSeq, Dec 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See SPINK9 in Genome Data Viewer
Location:
5q32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (148323219..148341974)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (147715122..147719412)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546294 Neighboring gene piggyBac transposable element derived 4 pseudogene 3 Neighboring gene serine peptidase inhibitor Kazal type 7 Neighboring gene F-box protein 38 Neighboring gene PRELI domain containing 3B pseudogene 9 Neighboring gene uncharacterized LOC107986462 Neighboring gene 5-hydroxytryptamine receptor 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
serine protease inhibitor Kazal-type 9
Names
lymphoepithelial Kazal-type-related inhibitor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040433.2NP_001035523.1  serine protease inhibitor Kazal-type 9 precursor

    See identical proteins and their annotated locations for NP_001035523.1

    Status: REVIEWED

    Source sequence(s)
    AC091948, AY396740
    Consensus CDS
    CCDS34269.1
    UniProtKB/Swiss-Prot
    Q5DT21
    Related
    ENSP00000367139.1, ENST00000377906.2
    Conserved Domains (1) summary
    pfam00050
    Location:3286
    Kazal_1; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    148323219..148341974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009709.1XP_016865198.1  serine protease inhibitor Kazal-type 9 isoform X1

    UniProtKB/TrEMBL
    D6RJC5
    Related
    ENSP00000427240.2, ENST00000511717.6
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