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TMEM72 transmembrane protein 72 [ Homo sapiens (human) ]

Gene ID: 643236, updated on 25-Jan-2022

Summary

Official Symbol
TMEM72provided by HGNC
Official Full Name
transmembrane protein 72provided by HGNC
Primary source
HGNC:HGNC:31658
See related
Ensembl:ENSG00000187783 AllianceGenome:HGNC:31658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KSP37; C10orf127
Summary
This gene encodes a transmembrane protein which may be expressed specifically in the kidney. [provided by RefSeq, Sep 2016]
Expression
Biased expression in kidney (RPKM 17.1), colon (RPKM 1.6) and 1 other tissue See more
Orthologs
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Genomic context

See TMEM72 in Genome Data Viewer
Location:
10q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (44911337..44937010)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45406785..45432458)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9 pseudogene 21 Neighboring gene TMEM72 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 7362 Neighboring gene Sharpr-MPRA regulatory region 11970 Neighboring gene Sharpr-MPRA regulatory region 2327 Neighboring gene Ras association domain family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC157906, DKFZp686M0585

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 72
Names
kidney-specific secretory protein of 37 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051584.1 RefSeqGene

    Range
    5022..30695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123376.3NP_001116848.1  transmembrane protein 72 isoform 1

    See identical proteins and their annotated locations for NP_001116848.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL353801, BC127790
    Consensus CDS
    CCDS41504.1
    UniProtKB/Swiss-Prot
    A0PK05
    Related
    ENSP00000374234.4, ENST00000389583.5
    Conserved Domains (1) summary
    pfam16054
    Location:4189
    TMEM72; Transmembrane protein family 72
  2. NM_001345926.2NP_001332855.1  transmembrane protein 72 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    AL353801, BC127789
    Consensus CDS
    CCDS86085.1
    UniProtKB/Swiss-Prot
    A0PK05
    Related
    ENSP00000439911.1, ENST00000544540.5
    Conserved Domains (1) summary
    pfam16054
    Location:171
    TMEM72; Transmembrane protein family 72

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    44911337..44937010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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