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FBRS fibrosin [ Homo sapiens (human) ]

Gene ID: 64319, updated on 1-Jun-2020

Summary

Official Symbol
FBRSprovided by HGNC
Official Full Name
fibrosinprovided by HGNC
Primary source
HGNC:HGNC:20442
See related
Ensembl:ENSG00000156860 MIM:608601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBS; FBS1
Summary
Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 34.3), bone marrow (RPKM 18.4) and 24 other tissues See more
Orthologs

Genomic context

See FBRS in Genome Data Viewer
Location:
16p11.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (30658431..30670810)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (30675778..30682131)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 689 Neighboring gene proline rich 14 Neighboring gene RNA, U6 small nuclear 416, pseudogene Neighboring gene Sharpr-MPRA regulatory region 39 Neighboring gene uncharacterized LOC730183

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11618

General protein information

Preferred Names
probable fibrosin-1
Names
fibrogenic lymphokine
fibrosin 1
probable fibrosin-1 long transcript protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105079.3NP_001098549.2  probable fibrosin-1

    Status: VALIDATED

    Source sequence(s)
    AC093249
    Consensus CDS
    CCDS45462.2
    UniProtKB/Swiss-Prot
    Q9HAH7
    UniProtKB/TrEMBL
    B3KTZ7, J3KNZ9
    Related
    ENSP00000348489.5, ENST00000356166.11
    Conserved Domains (1) summary
    pfam15336
    Location:602802
    Auts2; Autism susceptibility gene 2 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    30658431..30670810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545916.3XP_011544218.1  probable fibrosin-1 isoform X1

    Conserved Domains (1) summary
    pfam15336
    Location:592792
    Auts2; Autism susceptibility gene 2 protein
  2. XM_011545917.3XP_011544219.1  probable fibrosin-1 isoform X2

    Conserved Domains (1) summary
    pfam15336
    Location:592792
    Auts2; Autism susceptibility gene 2 protein
  3. XM_011545919.3XP_011544221.1  probable fibrosin-1 isoform X3

    Conserved Domains (1) summary
    pfam15336
    Location:580780
    Auts2; Autism susceptibility gene 2 protein

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022452.1: Suppressed sequence

    Description
    NM_022452.1: This RefSeq was permanently suppressed because the CDS was partial.
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