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NOC3L NOC3 like DNA replication regulator [ Homo sapiens (human) ]

Gene ID: 64318, updated on 3-May-2020

Summary

Official Symbol
NOC3Lprovided by HGNC
Official Full Name
NOC3 like DNA replication regulatorprovided by HGNC
Primary source
HGNC:HGNC:24034
See related
Ensembl:ENSG00000173145 MIM:610769
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD24; FAD24; C10orf117
Expression
Ubiquitous expression in thyroid (RPKM 7.2), testis (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See NOC3L in Genome Data Viewer
Location:
10q23.33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (94314907..94362959, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (96092989..96122715, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phospholipase C epsilon 1 Neighboring gene RNA, U6 small nuclear 657, pseudogene Neighboring gene PLCE1 antisense RNA 1 Neighboring gene TBC1 domain family member 12 Neighboring gene helicase, lymphoid specific

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
nucleolar complex protein 3 homolog
Names
NOC3 protein homolog
NOC3L DNA replication regulator
factor for adipocyte differentiation 24
nucleolar complex associated 3 homolog
nucleolar complex-associated protein 3-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022451.11NP_071896.8  nucleolar complex protein 3 homolog

    See identical proteins and their annotated locations for NP_071896.8

    Status: VALIDATED

    Source sequence(s)
    AI632144, AK091246, BC049850, BX505710
    Consensus CDS
    CCDS7433.1
    UniProtKB/Swiss-Prot
    Q8WTT2
    Related
    ENSP00000360412.3, ENST00000371361.3
    Conserved Domains (3) summary
    COG5117
    Location:113711
    NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
    pfam03914
    Location:555708
    CBF; CBF/Mak21 family
    pfam07540
    Location:214308
    NOC3p; Nucleolar complex-associated protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    94314907..94362959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016544.1XP_016872033.1  nucleolar complex protein 3 homolog isoform X1

RNA

  1. XR_002957007.1 RNA Sequence

  2. XR_001747182.2 RNA Sequence

  3. XR_001747181.2 RNA Sequence

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