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NOC3L NOC3 like DNA replication regulator [ Homo sapiens (human) ]

Gene ID: 64318, updated on 17-Jun-2024

Summary

Official Symbol
NOC3Lprovided by HGNC
Official Full Name
NOC3 like DNA replication regulatorprovided by HGNC
Primary source
HGNC:HGNC:24034
See related
Ensembl:ENSG00000173145 MIM:610769; AllianceGenome:HGNC:24034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AD24; FAD24; C10orf117
Summary
Enables RNA binding activity. Predicted to be involved in DNA replication initiation. Predicted to act upstream of or within fat cell differentiation. Located in mitochondrion; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.2), testis (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See NOC3L in Genome Data Viewer
Location:
10q23.33
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (94314907..94362939, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (95193999..95242036, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (96092983..96122696, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene phospholipase C epsilon 1 Neighboring gene RNA, U6 small nuclear 657, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3787 Neighboring gene PLCE1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96117703-96118368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96118369-96119034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2633 Neighboring gene MPRA-validated peak1050 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:96140095-96141294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3790 Neighboring gene TBC1 domain family member 12 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96304601-96305225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305226-96305850 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305851-96306474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335135-96335636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335637-96336136 Neighboring gene MPRA-validated peak1052 silencer Neighboring gene helicase, lymphoid specific

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12820

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nucleolar complex protein 3 homolog
Names
NOC3 protein homolog
NOC3L DNA replication regulator
factor for adipocyte differentiation 24
nucleolar complex associated 3 homolog
nucleolar complex-associated protein 3-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022451.11NP_071896.8  nucleolar complex protein 3 homolog

    See identical proteins and their annotated locations for NP_071896.8

    Status: VALIDATED

    Source sequence(s)
    AI632144, AK091246, BC049850, BX505710
    Consensus CDS
    CCDS7433.1
    UniProtKB/Swiss-Prot
    Q8WTT2, Q9H5M6, Q9H9D8
    UniProtKB/TrEMBL
    A8K905
    Related
    ENSP00000360412.3, ENST00000371361.3
    Conserved Domains (3) summary
    COG5117
    Location:113711
    NOC3; Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]
    pfam03914
    Location:555708
    CBF; CBF/Mak21 family
    pfam07540
    Location:214308
    NOC3p; Nucleolar complex-associated protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    94314907..94362939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425641.1XP_047281597.1  nucleolar complex protein 3 homolog isoform X2

  2. XM_047425640.1XP_047281596.1  nucleolar complex protein 3 homolog isoform X1

RNA

  1. XR_002957007.2 RNA Sequence

  2. XR_007061982.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    95193999..95242036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366569.1XP_054222544.1  nucleolar complex protein 3 homolog isoform X2

  2. XM_054366568.1XP_054222543.1  nucleolar complex protein 3 homolog isoform X1

RNA

  1. XR_008488248.1 RNA Sequence