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Pfn1 profilin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64303, updated on 25-Nov-2021

Summary

Official Symbol
Pfn1provided by RGD
Official Full Name
profilin 1provided by RGD
Primary source
RGD:621825
See related
EnsemblRapid:ENSRNOG00000003975
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
regulates actin polymerization; may reorganize the actin cytoskeleton; may be involved in the pathogenesis of glomerulonephritis [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 2826.1), Spleen (RPKM 2748.0) and 9 other tissues See more
Orthologs
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Genomic context

See Pfn1 in Genome Data Viewer
Location:
10q24
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (55365263..55367968, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (57273003..57275708, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 11 Neighboring gene ring finger protein 167 Neighboring gene enolase 3 Neighboring gene sperm associated antigen 7

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding TAS
Traceable Author Statement
more info
PubMed 
enables actin monomer binding ISO
Inferred from Sequence Orthology
more info
 
enables adenyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin polymerization or depolymerization TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ruffle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of viral transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in synapse maturation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
profilin-1
Names
profilin I

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022511.2NP_071956.2  profilin-1

    See identical proteins and their annotated locations for NP_071956.2

    Status: PROVISIONAL

    Source sequence(s)
    BC062405
    UniProtKB/Swiss-Prot
    P62963
    Related
    ENSRNOP00000005370.3, ENSRNOT00000005370.7
    Conserved Domains (1) summary
    smart00392
    Location:2140
    PROF; Profilin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    55365263..55367968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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