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SMIM5 small integral membrane protein 5 [ Homo sapiens (human) ]

Gene ID: 643008, updated on 11-Sep-2019

Summary

Official Symbol
SMIM5provided by HGNC
Official Full Name
small integral membrane protein 5provided by HGNC
Primary source
HGNC:HGNC:40030
See related
Ensembl:ENSG00000204323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP12104; C17orf109
Expression
Broad expression in stomach (RPKM 3.8), kidney (RPKM 3.7) and 19 other tissues See more
Orthologs

Genomic context

See SMIM5 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75633434..75641406)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73629514..73637486)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene myosin XVB Neighboring gene RecQ like helicase 5 Neighboring gene HNF1 motif-containing MPRA enhancer 181 Neighboring gene uncharacterized LOC107985013 Neighboring gene small integral membrane protein 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ31206, DKFZp451K2118

Gene Ontology Provided by GOA

Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small integral membrane protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162995.2NP_001156467.1  small integral membrane protein 5

    See identical proteins and their annotated locations for NP_001156467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    BC027861, BI712658, CA413024
    Consensus CDS
    CCDS54165.1
    UniProtKB/Swiss-Prot
    Q71RC9
    Related
    ENSP00000364363.3, ENST00000375215.3
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)

RNA

  1. NR_028439.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' end, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC087749, AK055768, AL832643, CA413024

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75633434..75641406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024944.1XP_016880433.1  small integral membrane protein 5 isoform X2

  2. XM_011525116.2XP_011523418.1  small integral membrane protein 5 isoform X1

  3. XM_017024947.2XP_016880436.1  small integral membrane protein 5 isoform X4

    UniProtKB/Swiss-Prot
    Q71RC9
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)
  4. XM_017024945.2XP_016880434.1  small integral membrane protein 5 isoform X3

  5. XM_011525119.2XP_011523421.1  small integral membrane protein 5 isoform X4

    See identical proteins and their annotated locations for XP_011523421.1

    UniProtKB/Swiss-Prot
    Q71RC9
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)
  6. XM_017024946.1XP_016880435.1  small integral membrane protein 5 isoform X4

    UniProtKB/Swiss-Prot
    Q71RC9
    Related
    ENSP00000477017.1, ENST00000537494.1
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)
  7. XM_017024948.1XP_016880437.1  small integral membrane protein 5 isoform X4

    UniProtKB/Swiss-Prot
    Q71RC9
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)
  8. XM_011525118.2XP_011523420.1  small integral membrane protein 5 isoform X4

    See identical proteins and their annotated locations for XP_011523420.1

    UniProtKB/Swiss-Prot
    Q71RC9
    Conserved Domains (1) summary
    pfam15831
    Location:857
    DUF4713; Domain of unknown function (DUF4713)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_015452.1: Suppressed sequence

    Description
    NR_015452.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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