Ptges prostaglandin E synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgesprovided by MGI
Official Full Name: prostaglandin E synthaseprovided by MGI
Primary source: MGI:MGI:1927593
See related: Ensembl:ENSMUSG00000050737 AllianceGenome:MGI:1927593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pges; mPGES; mPGES-1; D2Ertd369e; 2410099E23Rik
Summary: Enables prostaglandin-D synthase activity. Involved in prostaglandin biosynthetic process; regulation of fever generation; and sensory perception of pain. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of prostaglandin secretion; and prostaglandin metabolic process. Located in cytoplasm and nuclear envelope lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in genital fat pad adult (RPKM 29.4), subcutaneous fat pad adult (RPKM 26.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.75 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30779483..30793309, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30889471..30931020, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective.
Title: Transient inhibition of microsomal prostaglandin E synthase-1 after status epilepticus blunts brain inflammation and is neuroprotective.
The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.
Title: The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.
Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity.
Title: Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity.
IL-17-induced inflammation modulates the mPGES-1/PPAR-gamma pathway in monocytes/macrophages.
Title: IL-17-induced inflammation modulates the mPGES-1/PPAR-γ pathway in monocytes/macrophages.
Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
Title: Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis.
Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Title: Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
PTGES/PGE2 signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
Title: PTGES/PGE(2) signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.
These results suggest that mPGES-1 enhances lung tumor metastasis by inducing accumulation of bone marrow-derived myeloid-derived suppressor cells
Title: Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b(+)Gr1(+)MDSCs from bone marrow.
deletion of mPges-1 in myeloid cells has favorable effects on post-MI surviva
Title: Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.
attenuation of prostaglandin E2 production by mPGES-1 ablation enhanced the TNF-alpha-triggered inflammatory response and hepatocyte apoptosis in diet-induced non-alcoholic steatohepatitis.
Title: Augmented liver inflammation in a microsomal prostaglandin E synthase 1 (mPGES-1)-deficient diet-induced mouse NASH model.

Submit: New GeneRIF Correction See all GeneRIFs (120)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptges (e-PCR), detects polymorphism
- UniSTS:528234

D2Ertd369e (e-PCR), detects polymorphism
- UniSTS:167315

RH129128 (e-PCR)
- UniSTS:212436

C81628 (e-PCR)
- UniSTS:158946

Homology

Homologs of the Ptges gene: The Ptges gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 495 organisms have orthologs with human gene Ptges
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-D synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin-D synthase activity	TAS Traceable Author Statement more info	PubMed
enables prostaglandin-E synthase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables prostaglandin-E synthase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in prostaglandin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fever generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	IDA Inferred from Direct Assay more info	PubMed
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin E synthase

Names: glutathione peroxidase PTGES; glutathione transferase PTGES; microsomal prostaglandin E synthase 1

NP_071860.1

EC 2.5.1.18

EC 5.3.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.