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Ptges prostaglandin E synthase [ Mus musculus (house mouse) ]

Gene ID: 64292, updated on 11-Jun-2025
Official Symbol
Ptgesprovided by MGI
Official Full Name
prostaglandin E synthaseprovided by MGI
Primary source
MGI:MGI:1927593
See related
Ensembl:ENSMUSG00000050737 AllianceGenome:MGI:1927593
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pges; mPGES; mPGES-1; D2Ertd369e; 2410099E23Rik
Summary
Enables prostaglandin-D synthase activity and prostaglandin-E synthase activity. Involved in cyclooxygenase pathway; regulation of fever generation; and sensory perception of pain. Acts upstream of or within negative regulation of cell population proliferation; positive regulation of prostaglandin secretion; and prostaglandin metabolic process. Located in endoplasmic reticulum membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human PTGES (prostaglandin E synthase). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in genital fat pad adult (RPKM 29.4), subcutaneous fat pad adult (RPKM 26.4) and 14 other tissues See more
Orthologs
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See Ptges in Genome Data Viewer
Location:
2 B; 2 21.75 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30779483..30793309, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30889471..30931020, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10091 Neighboring gene ankyrin repeat and SOCS box-containing 6 Neighboring gene paired related homeobox 2 Neighboring gene predicted gene, 52550 Neighboring gene predicted gene, 57831 Neighboring gene STARR-seq mESC enhancer starr_04126 Neighboring gene peptidylprolyl isomerase A pseudogene 2_387.1 Neighboring gene torsin family 1, member B Neighboring gene torsin family 1, member A (torsin A)

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione binding IEA
Inferred from Electronic Annotation
more info
 
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables prostaglandin-D synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin-D synthase activity TAS
Traceable Author Statement
more info
PubMed 
enables prostaglandin-E synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prostaglandin-E synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin-E synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables prostaglandin-E synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin-E synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in cyclooxygenase pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of prostaglandin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in prostaglandin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
prostaglandin E synthase
Names
glutathione peroxidase PTGES
glutathione transferase PTGES
microsomal prostaglandin E synthase 1
NP_071860.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022415.3NP_071860.1  prostaglandin E synthase

    See identical proteins and their annotated locations for NP_071860.1

    Status: VALIDATED

    Source sequence(s)
    AK080897, AK167015, BY691798
    Consensus CDS
    CCDS15889.1
    UniProtKB/Swiss-Prot
    Q3T9C5, Q9JM51
    UniProtKB/TrEMBL
    Q3UDM3
    Related
    ENSMUSP00000099916.4, ENSMUST00000102852.6
    Conserved Domains (1) summary
    pfam01124
    Location:17147
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30779483..30793309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)