lbx2 ladybird homeobox 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lbx2provided by ZNC
Official Full Name: ladybird homeobox 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-001206-2
See related: Ensembl:ENSDARG00000025131 AllianceGenome:ZFIN:ZDB-GENE-001206-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lbx; lbx1; lbx1h; fc26c12; homeobox; zgc:92170; wu:fc26c12; SI:zC207O21.2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in several processes, including positive regulation of convergent extension involved in gastrulation; positive regulation of non-canonical Wnt signaling pathway; and posterior lateral line development. Acts upstream of or within muscle cell development and regulation of canonical Wnt signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; fin; mesoderm; musculature system; and presumptive paraxial mesoderm. Orthologous to human LBX2 (ladybird homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	14	NC_133189.1 (5915668..5918736)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5385856..5388924)

Chromosome 14 - NC_133189.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

controls the Wnt/beta-catenin signalling pathway in the posterior lateral and ventral mesoderm of the embryo at the gastrula stage
Title: Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway.
The key noncanonical Wnt signaling components Wnt5, Dvl, and RhoA are downstream effectors involved in the regulative roles of lbx2 in convergence and extension movement and hypaxial myogenesis during zebrafish embryogenesis.
Title: Role of lbx2 in the noncanonical Wnt signaling pathway for convergence and extension movements and hypaxial myogenesis in zebrafish.
disassociation of PPL nerve extension with PLL primordial migration in some lbx2 morphants suggests that pathfinding of the PLL primordium and the lateral line nerve may be regulated independently
Title: Role of zebrafish lbx2 in embryonic lateral line development.
A loss of Pbx2 and Pbx4 causes a significant reduction of hindbrain and spinal cord expression of lbx1 genes.
Title: Pbx-dependent regulation of lbx gene expression in developing zebrafish embryos.
Results elucidate a new function of Lbx2 as a regulator of myofibril formation
Title: Lbx2 regulates formation of myofibrils.

Submit: New GeneRIF Correction

General gene information

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Markers

fc26c12.x1 (e-PCR)
- UniSTS:193302

fc26c12.x1 (e-PCR)
- UniSTS:193303

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in embryonic axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within muscle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of convergent extension involved in gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior lateral line neuromast deposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in posterior lateral line neuromast primordium migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor LBX2

Names: lady bird-like homeobox 1 homolog; ladybird homeobox homolog 1; ladybird homeobox homolog 2; ladybird homeobox protein homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.