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TRIM49C tripartite motif containing 49C [ Homo sapiens (human) ]

Gene ID: 642612, updated on 5-Aug-2022

Summary

Official Symbol
TRIM49Cprovided by HGNC
Official Full Name
tripartite motif containing 49Cprovided by HGNC
Primary source
HGNC:HGNC:38877
See related
Ensembl:ENSG00000204449 AllianceGenome:HGNC:38877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIM49L2
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response; protein ubiquitination; and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

See TRIM49C in Genome Data Viewer
Location:
11q14.3
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (90031106..90073531)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (89951193..89962103)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89764274..89775193)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 53A, pseudogene Neighboring gene tripartite motif containing 64B pseudogene Neighboring gene ANKRD33B pseudogene 10 Neighboring gene tripartite motif containing 64E, pseudogene Neighboring gene upstream binding transcription factor like 1 Neighboring gene small nucleolar RNA SNORD56

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC161748

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tripartite motif-containing protein 49C
Names
Tripartite motif-containing protein LOC642612
tripartite motif containing 49-like 2
tripartite motif-containing protein 49-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195234.1NP_001182163.1  tripartite motif-containing protein 49C

    See identical proteins and their annotated locations for NP_001182163.1

    Status: VALIDATED

    Source sequence(s)
    AP004607
    Consensus CDS
    CCDS53694.1
    UniProtKB/Swiss-Prot
    P0CI26, Q9NS80
    Related
    ENSP00000388299.1, ENST00000448984.1
    Conserved Domains (2) summary
    cl02614
    Location:285448
    SPRY; SPRY domain
    cl17238
    Location:1545
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    90031106..90073531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018126.2XP_016873615.1  tripartite motif-containing protein 49C isoform X1

  2. XM_024448656.2XP_024304424.1  tripartite motif-containing protein 49C isoform X2

    Conserved Domains (2) summary
    cd16603
    Location:1257
    RING-HC_TRIM43_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM43, TRIM48, TRIM49, TRIM51, TRIM64, TRIM77 and similar proteins
    cl02614
    Location:285441
    SPRY; SPRY domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    89951193..89962103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)