AKAIN1 A-kinase anchor inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AKAIN1provided by HGNC
Official Full Name: A-kinase anchor inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:28285
See related: Ensembl:ENSG00000231824 MIM:616427; AllianceGenome:HGNC:28285
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C18orf42
Summary: Enables protein kinase A binding activity. Involved in protein localization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression: Biased expression in adrenal (RPKM 1.4), brain (RPKM 0.1) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 18p11.31

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (5142911..5197691, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (5305184..5359979, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (5142910..5197690, complement)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that C18orf42 may be a novel PKA signaling gene that serves as an endogenous disruptor peptide for PKA-AKAP interactions.
Title: Hypothetical gene C18orf42 encodes a novel protein kinase A-binding protein.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D18S943E (e-PCR)
- UniSTS:150535

GDB:313337 (e-PCR)
- UniSTS:52984

RH91766 (e-PCR)
- UniSTS:88061

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A-kinase anchor protein inhibitor 1

Names: A kinase (PRKA) anchor inhibitor 1; A-kinase anchor protein C18orf42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145194.2 → NP_001138666.1 A-kinase anchor protein inhibitor 1 isoform 1

See identical proteins and their annotated locations for NP_001138666.1

Status: VALIDATED

Source sequence(s)

AP001496, AP005380

Consensus CDS

CCDS54179.1

UniProtKB/Swiss-Prot

P0CW23

Related

ENSP00000399075.3, ENST00000434239.4

Conserved Domains (1) summary

pfam10470
Location:12 → 44

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
NM_001330553.2 → NP_001317482.1 A-kinase anchor protein inhibitor 1 isoform 2

Status: VALIDATED

Source sequence(s)

AI681285, AP001496, AP005380, EL953233, HY128307

Consensus CDS

CCDS82235.1

UniProtKB/TrEMBL

J3KS16

Related

ENSP00000462259.1, ENST00000580650.1

Conserved Domains (1) summary

pfam10470
Location:19 → 51

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein