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AKAIN1 A-kinase anchor inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 642597, updated on 5-Jul-2025
Official Symbol
AKAIN1provided by HGNC
Official Full Name
A-kinase anchor inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:28285
See related
Ensembl:ENSG00000231824 MIM:616427; AllianceGenome:HGNC:28285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf42
Summary
Enables protein kinase A binding activity. Involved in protein localization. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in adrenal (RPKM 1.4), brain (RPKM 0.1) and 1 other tissue See more
Orthologs
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See AKAIN1 in Genome Data Viewer
Location:
18p11.31
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (5142911..5197691, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (5305184..5359979, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (5142910..5197690, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1892 Neighboring gene NANOG hESC enhancer GRCh37_chr18:5097103-5097620 Neighboring gene biorientation of chromosomes in cell division 1 pseudogene 2 Neighboring gene uncharacterized LOC124904341 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:5214004-5215203 Neighboring gene long intergenic non-protein coding RNA 526

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
A-kinase anchor protein inhibitor 1
Names
A kinase (PRKA) anchor inhibitor 1
A-kinase anchor protein C18orf42

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145194.2NP_001138666.1  A-kinase anchor protein inhibitor 1 isoform 1

    See identical proteins and their annotated locations for NP_001138666.1

    Status: VALIDATED

    Source sequence(s)
    AP001496, AP005380
    Consensus CDS
    CCDS54179.1
    UniProtKB/Swiss-Prot
    P0CW23
    Related
    ENSP00000399075.3, ENST00000434239.4
    Conserved Domains (1) summary
    pfam10470
    Location:1244
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
  2. NM_001330553.2NP_001317482.1  A-kinase anchor protein inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI681285, AP001496, AP005380, EL953233, HY128307
    Consensus CDS
    CCDS82235.1
    UniProtKB/TrEMBL
    J3KS16
    Related
    ENSP00000462259.1, ENST00000580650.1
    Conserved Domains (1) summary
    pfam10470
    Location:1951
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    5142911..5197691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    5305184..5359979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)