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AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 [ Homo sapiens (human) ]

Gene ID: 642517, updated on 22-May-2022

Summary

Official Symbol
AGAP9provided by HGNC
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 9provided by HGNC
Primary source
HGNC:HGNC:23463
See related
Ensembl:ENSG00000204172 AllianceGenome:HGNC:23463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGAP-9; CTGLF6; bA301J7.2
Summary
Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 15.8), skin (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

See AGAP9 in Genome Data Viewer
Location:
10q11.22
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (47501854..47523638, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (48393155..48414940, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48215724..48237508)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902420 Neighboring gene BMS1P2-AGAP9 readthrough Neighboring gene annexin A8 Neighboring gene uncharacterized LOC124902421 Neighboring gene family with sequence similarity 25 member G Neighboring gene RNA, 5S ribosomal pseudogene 312

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough BMS1P2-AGAP9

Readthrough gene: BMS1P2-AGAP9, Included gene: BMS1P2

Homology

Clone Names

  • FLJ00312, FLJ39589, FLJ99065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9
Names
centaurin-gamma-like family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190810.1NP_001177739.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 9

    Status: VALIDATED

    Source sequence(s)
    BC171845, BC171847
    Consensus CDS
    CCDS73125.1
    UniProtKB/Swiss-Prot
    Q5VTM2
    Related
    ENSP00000392206.2, ENST00000452145.6
    Conserved Domains (6) summary
    cd01250
    Location:280444
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00023
    Location:623643
    Ank; Ankyrin repeat
    pfam00169
    Location:283442
    PH; PH domain
    pfam01412
    Location:466580
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:596643
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:591621
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    47501854..47523638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    48393155..48414940 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)