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MS4A5 membrane spanning 4-domains A5 [ Homo sapiens (human) ]

Gene ID: 64232, updated on 26-Nov-2021

Summary

Official Symbol
MS4A5provided by HGNC
Official Full Name
membrane spanning 4-domains A5provided by HGNC
Primary source
HGNC:HGNC:13374
See related
Ensembl:ENSG00000166930 MIM:606499
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TETM4; CD20L2; CD20-L2
Summary
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. Though this member is not expressed in hematopoietic cells specifically, it may be involved in signal transduction like many of its related family members. The gene encoding this protein is localized to 11q12, among a cluster of family members. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 16.2) See more
Orthologs
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Genomic context

See MS4A5 in Genome Data Viewer
Location:
11q12.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (60429572..60447792)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (60197045..60215265)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene membrane spanning 4-domains A7 Neighboring gene membrane spanning 4-domains A14 Neighboring gene membrane spanning 4-domains A1 Neighboring gene membrane spanning 4-domains A12 Neighboring gene uncharacterized LOC105369320

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Potential readthrough

Included gene: MS4A1

Homology

Clone Names

  • MGC34184

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
membrane-spanning 4-domains subfamily A member 5
Names
CD20 antigen-like 2
testis-expressed transmembrane protein 4
testis-expressed transmembrane-4 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023945.3NP_076434.2  membrane-spanning 4-domains subfamily A member 5

    See identical proteins and their annotated locations for NP_076434.2

    Status: REVIEWED

    Source sequence(s)
    AP003127, BC029884
    Consensus CDS
    CCDS7987.1
    UniProtKB/Swiss-Prot
    Q9H3V2
    Related
    ENSP00000300190.2, ENST00000300190.7
    Conserved Domains (1) summary
    pfam04103
    Location:49189
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    60429572..60447792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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