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FAM110C family with sequence similarity 110 member C [ Homo sapiens (human) ]

Gene ID: 642273, updated on 1-Jun-2020

Summary

Official Symbol
FAM110Cprovided by HGNC
Official Full Name
family with sequence similarity 110 member Cprovided by HGNC
Primary source
HGNC:HGNC:33340
See related
Ensembl:ENSG00000184731 MIM:611395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in esophagus (RPKM 9.1), colon (RPKM 5.4) and 20 other tissues See more
Orthologs

Genomic context

See FAM110C in Genome Data Viewer
Location:
2p25.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (38814..47077, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38814..47042, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373324 Neighboring gene SH3 and SYLF domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Whole genome association scan for genetic polymorphisms influencing information processing speed.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell projection assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077710.3NP_001071178.2  protein FAM110C

    See identical proteins and their annotated locations for NP_001071178.2

    Status: VALIDATED

    Source sequence(s)
    AC097643
    Consensus CDS
    CCDS42645.1
    UniProtKB/Swiss-Prot
    Q1W6H9
    Related
    ENSP00000328347.4, ENST00000327669.5
    Conserved Domains (2) summary
    pfam14160
    Location:194303
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:1449
    FAM110_N; Centrosome-associated N terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    38814..47077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004691.1XP_016860180.1  protein FAM110C isoform X2

  2. XM_011510372.2XP_011508674.1  protein FAM110C isoform X4

    See identical proteins and their annotated locations for XP_011508674.1

    Conserved Domains (2) summary
    pfam14160
    Location:194303
    FAM110_C; Centrosome-associated C terminus
    pfam14161
    Location:1449
    FAM110_N; Centrosome-associated N terminus
  3. XM_017004689.1XP_016860178.1  protein FAM110C isoform X1

  4. XM_017004690.1XP_016860179.1  protein FAM110C isoform X1

  5. XM_017004692.1XP_016860181.1  protein FAM110C isoform X3

RNA

  1. XR_001738890.1 RNA Sequence

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