Format

Send to:

Choose Destination

ATL2 atlastin GTPase 2 [ Homo sapiens (human) ]

Gene ID: 64225, updated on 3-May-2020

Summary

Official Symbol
ATL2provided by HGNC
Official Full Name
atlastin GTPase 2provided by HGNC
Primary source
HGNC:HGNC:24047
See related
Ensembl:ENSG00000119787 MIM:609368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
aip-2; ARL3IP2; ARL6IP2; atlastin2
Expression
Ubiquitous expression in thyroid (RPKM 13.5), skin (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See ATL2 in Genome Data Viewer
Location:
2p22.2-p22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (38293954..38378584, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38522027..38604432, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374467 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 25 Neighboring gene uncharacterized LOC105374468 Neighboring gene long intergenic non-protein coding RNA 1883

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum tubular network membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum tubular network membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
atlastin-2
Names
ADP-ribosylation factor-like protein 6-interacting protein 2
ARL-6-interacting protein 2
NP_001129145.1
NP_001295005.1
NP_001317387.1
NP_001317388.1
NP_001317389.1
NP_001317390.1
NP_001317391.1
NP_001317392.1
NP_001317393.1
NP_071769.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135673.4NP_001129145.1  atlastin-2 isoform 2

    See identical proteins and their annotated locations for NP_001129145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' terminal exon, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016995, AI630457, AK225190, BC039050
    Consensus CDS
    CCDS46260.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000368237.4, ENST00000378954.9
    Conserved Domains (1) summary
    pfam02263
    Location:70341
    GBP; Guanylate-binding protein, N-terminal domain
  2. NM_001308076.1NP_001295005.1  atlastin-2 isoform 3

    See identical proteins and their annotated locations for NP_001295005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, resulting in translation initiation at an alternate start codon, and uses an alternate splice acceptor site in the 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC016995, AI630457, AK302621, BC039050, BX507348
    Consensus CDS
    CCDS77402.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000390743.2, ENST00000452935.6
    Conserved Domains (1) summary
    pfam02263
    Location:52323
    GBP; Guanylate-binding protein, N-terminal domain
  3. NM_001330458.1NP_001317387.1  atlastin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016995, AK308894, BC039050, BC053508
    Consensus CDS
    CCDS86831.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000498813.1, ENST00000651368.1
    Conserved Domains (1) summary
    cl21455
    Location:1170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001330459.1NP_001317388.1  atlastin-2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC016995, AK294049, AK302621
    UniProtKB/Swiss-Prot
    Q8NHH9
  5. NM_001330460.1NP_001317389.1  atlastin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016995, AK294711, AK302621
    Consensus CDS
    CCDS82436.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    UniProtKB/TrEMBL
    B5MCN0, B7Z2H0
    Conserved Domains (1) summary
    cl21455
    Location:1170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_001330461.2NP_001317390.1  atlastin-2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC016995
    Consensus CDS
    CCDS82436.1
    UniProtKB/TrEMBL
    B5MCN0
    Related
    ENSP00000385446.1, ENST00000406122.5
    Conserved Domains (1) summary
    cl21455
    Location:1170
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. NM_001330462.1NP_001317391.1  atlastin-2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC016995
    Conserved Domains (1) summary
    pfam02263
    Location:65336
    GBP; Guanylate-binding protein, N-terminal domain
  8. NM_001330463.2NP_001317392.1  atlastin-2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate in-frame exon in the 3' region compared to variant 1. It encodes isoform (8), which is longer than isoform 1.
    Source sequence(s)
    AC016995
    Conserved Domains (1) summary
    pfam02263
    Location:70341
    GBP; Guanylate-binding protein, N-terminal domain
  9. NM_001330464.2NP_001317393.1  atlastin-2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC016995
  10. NM_022374.5NP_071769.2  atlastin-2 isoform 1

    See identical proteins and their annotated locations for NP_071769.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC016995, AI630457, AK026946, AK124434, BC039050
    Consensus CDS
    CCDS1795.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000415336.2, ENST00000419554.6
    Conserved Domains (1) summary
    pfam02263
    Location:70341
    GBP; Guanylate-binding protein, N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    38293954..38378584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center