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TFB2M transcription factor B2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 64216, updated on 21-Dec-2019

Summary

Official Symbol
TFB2Mprovided by HGNC
Official Full Name
transcription factor B2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:18559
See related
Ensembl:ENSG00000162851 MIM:607055
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hkp1; mtTFB2
Expression
Ubiquitous expression in adrenal (RPKM 13.7), kidney (RPKM 9.8) and 25 other tissues See more
Orthologs

Genomic context

See TFB2M in Genome Data Viewer
Location:
1q44
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (246540561..246566261, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (246703863..246729565, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SET and MYND domain containing 3 Neighboring gene uncharacterized LOC107985726 Neighboring gene long intergenic non-protein coding RNA 1743 Neighboring gene uncharacterized LOC105373271 Neighboring gene endogenous retrovirus group 3 member 1 pseudogene Neighboring gene consortin, connexin sorting protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22661, FLJ23182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
rRNA (adenine-N6,N6-)-dimethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coregulator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transcription IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion organization TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from mitochondrial promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from mitochondrial promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dimethyladenosine transferase 2, mitochondrial
Names
HCV NS5A-transactivated protein 5
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
h-mtTFB
h-mtTFB2
hTFB2M
hepatitis C virus NS5A-transactivated protein 5
mitochondrial 12S rRNA dimethylase 2
mitochondrial transcription factor B2
NP_071761.1
XP_011542550.1
XP_016857544.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022366.3NP_071761.1  dimethyladenosine transferase 2, mitochondrial

    See identical proteins and their annotated locations for NP_071761.1

    Status: VALIDATED

    Source sequence(s)
    AK026835, CK725134, DA038232
    Consensus CDS
    CCDS1627.1
    UniProtKB/Swiss-Prot
    Q9H5Q4
    Related
    ENSP00000355471.4, ENST00000366514.5
    Conserved Domains (1) summary
    cl17173
    Location:94379
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    246540561..246566261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544248.2XP_011542550.1  dimethyladenosine transferase 2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011542550.1

    Conserved Domains (1) summary
    cl17173
    Location:94278
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_017002055.1XP_016857544.1  dimethyladenosine transferase 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:39186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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